| Predicted Trait | |
| Reported Trait | Atrial fibrillation |
| Mapped Trait(s) | atrial fibrillation (EFO_0000275) |
| Score Construction | |
| PGS Name | GRS97_AF |
| Development Method | |
| Name | Genome-wide significant variants |
| Parameters | p < 1e-8, INFO score > 0.4, Hardy-Weinberg equilibrium p > 1e-6 |
| Variants | |
| Original Genome Build | hg19 |
| Number of Variants | 97 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000105 |
| Citation (link to publication) | Kloosterman M et al. Eur J Heart Fail (2020) |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST006061 Europe PMC: 29892015 |
8,967 individuals | African American or Afro-Caribbean | NR |
GWAS Catalog: GCST006061 Europe PMC: 29892015 |
537,409 individuals | European | NR |
GWAS Catalog: GCST006061 Europe PMC: 29892015 |
5,022 individuals | Hispanic or Latin American | NR |
GWAS Catalog: GCST006061 Europe PMC: 29892015 |
36,792 individuals | East Asian (Japanese) |
NR |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000916 | PSS000462| European Ancestry| 3,759 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation | OR: 2.13 [1.86, 2.44] | — | — | age, sex, PCs (1-10) of ancestry | — |
| PPM000913 | PSS000462| European Ancestry| 3,759 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation | OR: 2.12 [1.84, 2.45] | — | — | age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry | — |
| PPM000917 | PSS000461| European Ancestry| 2,262 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction | OR: 2.12 [1.77, 2.54] | — | — | age, sex, PCs (1-10) of ancestry | — |
| PPM000915 | PSS000460| European Ancestry| 530 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction | OR: 2.02 [1.37, 2.99] | — | — | age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry | — |
| PPM000914 | PSS000461| European Ancestry| 2,262 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction | OR: 2.08 [1.72, 2.5] | — | — | age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry | — |
| PPM000920 | PSS000462| European Ancestry| 3,759 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation | — | AUROC: 0.721 [0.704, 737.0] | — | PCs (1-10) of ancestry, CHARGE-AF risk factors (age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, myocardial infarction, diabetes) | — |
| PPM000919 | PSS000462| European Ancestry| 3,759 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation | — | AUROC: 0.606 [0.588, 0.624] | — | PCs (1-10) of ancestry | — |
| PPM000918 | PSS000460| European Ancestry| 530 individuals |
PGP000105 | Kloosterman M et al. Eur J Heart Fail (2020) |
Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction | OR: 1.82 [1.28, 2.59] | — | — | age, sex, PCs (1-10) of ancestry | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000460 | Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG. HFpEF defined as LVEF >/= 50% | — | [
|
— | European | — | BIOSTAT-CHF | BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014 |
| PSS000461 | Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG.HFrEF defined as LVEF <40% | — | [
|
— | European | — | BIOSTAT-CHF | BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014 |
| PSS000462 | Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG. | — | [ ,
70.0 % Male samples |
Mean = 72.8 years Sd = 11.5 years |
European | — | BIOSTAT-CHF | BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014 |