Polygenic Score (PGS) ID: PGS000342

Predicted Trait
Reported Trait Psoriatic arthritis
Mapped Trait(s) psoriatic arthritis (EFO_0003778)
Released in PGS Catalog: Nov. 20, 2020
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Score Details

Score Construction
PGS Name wGRS_PsA
Variants
Original Genome Build hg19
Number of Variants 11
Development Method
Name GWAS-significant variants, HLA-specific significant variants.
Parameters SNPs within candidate risk genes shown to be associated with Psoriasis only (PsO) or Psoriatic Arthritis (PsA) in large cohorts or genome-wide association studies.
PGS Source
PGS Catalog Publication (PGP) ID PGP000111
Citation (link to publication) Smith MP et al. J Psoriasis Psoriatic Arthritis (2020)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST003269
EuropePMC: 26626624
6,297 individuals European
GWAS Catalog: GCST003270
EuropePMC: 26626624
6,880 individuals European
EuropePMC: 25948071.0 0 individuals Not reported

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000971 PSS000490 PGP000111
Smith MP et al. (2020)
Reported Trait: Psoriatic arthritis AUROC: 0.562[0.506, 0.618]

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000490 Cases included physician-confirmed psoriatic arthritis (PsA). Controls inclded individuals with psoriasis with no history of joint symptoms (psoriasis only - PsO).
[
  • 140 cases
  • , 403 controls
]
Not reported