Polygenic Score (PGS) ID: PGS000351

Predicted Trait
Reported Trait Invasive epithelial ovarian cancer
Mapped Trait(s) ovarian carcinoma (EFO_0001075)
Released in PGS Catalog: Dec. 8, 2020
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS_EOC
Development Method
Name Genome-wide significant variants
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 30
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000117
Citation (link to publication) Barnes DR et al. Genet Med (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
322,760 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 27432226
[
  • 112,349 cases
  • , 124,985 controls
]
 European 71 cohorts
  • ABCFS
  • ,ABCTB
  • ,ACS
  • ,AOCS
  • ,ATBC
  • ,BBCC
  • ,BBCS
  • ,BCFR-AU
  • ,BCFR-NCA
  • ,BCFR-ONT
  • ,CAPS
  • ,CCFR
  • ,CGEMS
  • ,CPCS
  • ,CPSII
  • ,DFBBCS
  • ,DFCI
  • ,EMBRACE
  • ,EOPCS
  • ,EPIC
  • ,EPIC-Norfolk
  • ,ESTHER
  • ,FCCC
  • ,FHCRC
  • ,GC-HBOC
  • ,GEMO
  • ,GENICA
  • ,GESBC
  • ,GWAS_UK2
  • ,HEBCS
  • ,HEBON
  • ,HPFS
  • ,IPO-Porto
  • ,KORA
  • ,LI
  • ,MARIE
  • ,MAYO
  • ,MCBCS
  • ,MCCS
  • ,MEC
  • ,MOFFITT
  • ,NHS
  • ,NHS2
  • ,NordicDB
  • ,PBCS
  • ,PCMUS
  • ,PEGASUS-TIMI_54
  • ,PHS
  • ,PLCO
  • ,POSH
  • ,PPF-UNIS
  • ,Poland
  • ,ProMPT
  • ,ProtecT
  • ,QIMR
  • ,QLD
  • ,RFPCS
  • ,RS
  • ,SASBAC
  • ,SBCS
  • ,SEARCH
  • ,STHM
  • ,Seattle
  • ,TAMPERE
  • ,TNBCC
  • ,UKGPCS
  • ,ULM
  • ,USC
  • ,UTAH
  • ,WTCCC
  • ,kConFab
GWAS Catalog: GCST004462
Europe PMC: 28346442
 85,426 individuals European 95 cohorts
  • AOCS
  • ,BCFR-AU
  • ,BCFR-NY
  • ,BCFR-PA
  • ,BCFR-UTAH
  • ,BFBOCC
  • ,BMBSA
  • ,BOCC
  • ,BOCS
  • ,BRICOH
  • ,BioVU
  • ,CNIO
  • ,COH
  • ,CONSIT_TEAM
  • ,CopBCS
  • ,DEMOKRITOS
  • ,DFCI
  • ,DKFZ
  • ,DOVE
  • ,DPMS
  • ,EMBRACE
  • ,EPIC
  • ,FCCC
  • ,FOTS
  • ,FROC&GEOCS
  • ,G-FaST
  • ,GC-HBOC
  • ,GEMO
  • ,GOCS
  • ,Georgetown
  • ,HCSC
  • ,HEBCS
  • ,HEBON
  • ,HJOCS
  • ,HMOCS
  • ,HOCS
  • ,HOPE
  • ,HUNBOCS
  • ,HUOCS
  • ,HUVH
  • ,HeOCS
  • ,ICO
  • ,IHCC
  • ,INHERIT
  • ,IOVHBOCS
  • ,IPOBCS
  • ,KUMC
  • ,LAC-CCOC
  • ,LUHR
  • ,MALOVA
  • ,MAYO
  • ,MCGILL
  • ,MDACCS
  • ,MEC
  • ,MOCS
  • ,MOF
  • ,MSKCC
  • ,MUV
  • ,NC-BCFR
  • ,NCI
  • ,NCOCS
  • ,NECC
  • ,NHS
  • ,NJOCS
  • ,NNPIO
  • ,NOCS
  • ,NRG_ONCOLOGY
  • ,NSUHS
  • ,OCGN
  • ,OFBCR
  • ,OSUCCG
  • ,OUH
  • ,OVAL-BC
  • ,PLCO
  • ,POCS
  • ,SEARCH
  • ,SHMC
  • ,SWE
  • ,SWE-BRCA
  • ,Sisters
  • ,TBOCS
  • ,UBNS
  • ,UC
  • ,UCIOCS
  • ,UCSF
  • ,UDP
  • ,UKFOCR
  • ,UKGRFOCR
  • ,UPENN
  • ,UPITT
  • ,VFCTG
  • ,WCPSOCCI
  • ,WCRI
  • ,WOCS
  • ,kConFab

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001030 PSS000524|
European Ancestry|
18,935 individuals
 PGP000117 |
Barnes DR et al. Genet Med (2020)
 Reported Trait: Ovarian cancer in BRCA1 carriers HR: 1.31 [1.24, 1.39] — — birth cohort, PCs(1-4) of ancestry, family history in first- and second-degree relatives —
PPM001031 PSS000528|
European Ancestry|
12,339 individuals
 PGP000117 |
Barnes DR et al. Genet Med (2020)
 Reported Trait: Ovarian cancer in BRCA2 carriers HR: 1.42 [1.28, 1.58] — — birth cohort, PCs(1-4) of ancestry, family history in first- and second-degree relatives —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000528 — —
[
  • 718 cases
  • , 11,621 controls
]
,
0.0 % Male samples
 — European — 59 cohorts
  • BCFR-AU
  • ,BCFR-NY
  • ,BCFR-PA
  • ,BCFR-UTAH
  • ,BFBOCC
  • ,BMBSA
  • ,BRICOH
  • ,CNIO
  • ,COH
  • ,CONSIT_TEAM
  • ,CopBCS
  • ,DEMOKRITOS
  • ,DFCI
  • ,DKFZ
  • ,EMBRACE
  • ,FCCC
  • ,G-FaST
  • ,GC-HBOC
  • ,GEMO
  • ,Georgetown
  • ,HCSC
  • ,HEBCS
  • ,HEBON
  • ,HUNBOCS
  • ,HUVH
  • ,ICO
  • ,IHCC
  • ,INHERIT
  • ,IOVHBOCS
  • ,IPOBCS
  • ,KUMC
  • ,LUHR
  • ,MACBRCA
  • ,MAYO
  • ,MCGILL
  • ,MDACCS
  • ,MODSQUAD
  • ,MSKCC
  • ,MUV
  • ,NC-BCFR
  • ,NCI
  • ,NICCC
  • ,NNPIO
  • ,NRG_ONCOLOGY
  • ,NSUHS
  • ,OCGN
  • ,OFBCR
  • ,OUH
  • ,PiBCS
  • ,SWE-BRCA
  • ,UC
  • ,UCLA
  • ,UCSF
  • ,UKGRFOCR
  • ,UPENN
  • ,UPITT
  • ,VFCTG
  • ,WCRI
  • ,kConFab
 —
PSS000524 — —
[
  • 2,068 cases
  • , 16,867 controls
]
,
0.0 % Male samples
 — European — 59 cohorts
  • BCFR-AU
  • ,BCFR-NY
  • ,BCFR-PA
  • ,BCFR-UTAH
  • ,BFBOCC
  • ,BMBSA
  • ,BRICOH
  • ,CNIO
  • ,COH
  • ,CONSIT_TEAM
  • ,CopBCS
  • ,DEMOKRITOS
  • ,DFCI
  • ,DKFZ
  • ,EMBRACE
  • ,FCCC
  • ,G-FaST
  • ,GC-HBOC
  • ,GEMO
  • ,Georgetown
  • ,HCSC
  • ,HEBCS
  • ,HEBON
  • ,HUNBOCS
  • ,HUVH
  • ,ICO
  • ,IHCC
  • ,INHERIT
  • ,IOVHBOCS
  • ,IPOBCS
  • ,KUMC
  • ,LUHR
  • ,MACBRCA
  • ,MAYO
  • ,MCGILL
  • ,MDACCS
  • ,MODSQUAD
  • ,MSKCC
  • ,MUV
  • ,NC-BCFR
  • ,NCI
  • ,NICCC
  • ,NNPIO
  • ,NRG_ONCOLOGY
  • ,NSUHS
  • ,OCGN
  • ,OFBCR
  • ,OUH
  • ,PiBCS
  • ,SWE-BRCA
  • ,UC
  • ,UCLA
  • ,UCSF
  • ,UKGRFOCR
  • ,UPENN
  • ,UPITT
  • ,VFCTG
  • ,WCRI
  • ,kConFab
 —