Predicted Trait | |
Reported Trait | Any Cancer |
Mapped Trait(s) | cancer (EFO_0000311) |
Score Construction | |
PGS Name | PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-08_MGI_20200608 |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 14 |
Development Method | |
Name | GWAS Hits |
Parameters | LD Clumping (MAF >= 1%, r^2 <= 0.1) & P<=5e-08 |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000118 |
Citation (link to publication) | Fritsche LG et al. Am J Hum Genet (2020) |
Study Identifiers | Sample Numbers | Sample Ancestry |
---|---|---|
EuropePMC: 32424355 | [
|
European |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|
PheCode:10001; ICD9CM:; ICD10CM: | — | [
|
— | European | — | MGI | — |
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM001038 | PSS000533 | PGP000118 Fritsche LG et al. (2020) |
Reported Trait: Any Cancer | OR: 1.08 [1.041, 1.122] β: 0.0774 (0.0191) |
AUROC: 0.515 [0.503, 0.526] | Nagelkerke's Pseudo-R²: 0.00151 Brier score: 0.182 Odds Ratio (OR, top 1% vs. Rest): 1.48 [1.04, 2.1] |
age, sex, batch PCs 1-4 | Cancer PRSweb PheWAS Results: PRSWEB_PHECODE10001_UKBB-SAIGE-HRC-X10001_P_5e-08_MGI_20200608 |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000533 | Any Cancer PheCode | — | [
|
— | European | — | MGI | — |