Predicted Trait | |
Reported Trait | Pancreatic cancer |
Mapped Trait(s) | pancreatic carcinoma (EFO_0002618) |
Additional Trait Information | PheCode 157 |
Score Construction | |
PGS Name | PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_UKB_20200608 |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 10 |
Development Method | |
Name | P&T |
Parameters | LD Clumping (MAF >= 1%, r^2 <= 0.1) & P<=5e-09 |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000118 |
Citation (link to publication) | Fritsche LG et al. Am J Hum Genet (2020) |
Study Identifiers | Sample Numbers | Sample Ancestry |
---|---|---|
GWAS Catalog: GCST005434 EuropePMC: 29422604 |
21,536 individuals | European |
GWAS Catalog: GCST003758 EuropePMC: 27579533 |
13,952 individuals | European |
GWAS Catalog: GCST001749 EuropePMC: 23180869 |
642 individuals | European |
GWAS Catalog: GCST002553 EuropePMC: 25086665 |
6,785 individuals | European |
GWAS Catalog: GCST000456 EuropePMC: 19648918 |
3,576 individuals | European |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|
PheCode:157; ICD9:157, 157.0, 157.1, 157.2, 157.3, 157.4, 157.8, 157.9; ICD10:C25.0, C25.1, C25.2, C25.3, C25.4, C25.7, C25.8, C25.9 | — | [
|
— | European | — | UKB | — |
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM001071 | PSS000565 | PGP000118 Fritsche LG et al. (2020) |
Reported Trait: Pancreatic cancer | OR: 1.342 [1.199, 1.503] β: 0.294 (0.0577) |
AUROC: 0.579 [0.548, 0.611] | Nagelkerke's Pseudo-R²: 0.0157 Brier score: 0.0822 Odds Ratio (OR, top 1% vs. Rest): 1.64 [0.655, 4.12] |
age, sex, batch PCs 1-4 | Cancer PRSweb PheWAS Results: PRSWEB_PHECODE157_GWAS-Catalog-r2019-05-03-X157_PT_UKB_20200608 |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000565 | PheCode:157; ICD9:157, 157.0, 157.1, 157.2, 157.3, 157.4, 157.8, 157.9; ICD10:C25.0, C25.1, C25.2, C25.3, C25.4, C25.7, C25.8, C25.9 | — | [
|
— | European | — | UKB | — |