Predicted Trait | |
Reported Trait | Cancer of bronchus; lung |
Mapped Trait(s) | |
Additional Trait Information | PheCode 165.1 |
Score Construction | |
PGS Name | PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-08_MGI_20200608 |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 21 |
Development Method | |
Name | GWAS Hits |
Parameters | LD Clumping (MAF >= 1%, r^2 <= 0.1) & P<=5e-08 |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000118 |
Citation (link to publication) | Fritsche LG et al. Am J Hum Genet (2020) |
Study Identifiers | Sample Numbers | Sample Ancestry |
---|---|---|
GWAS Catalog: GCST004749 EuropePMC: 28604730 |
40,187 individuals | European |
GWAS Catalog: GCST004750 EuropePMC: 28604730 |
63,053 individuals | European |
GWAS Catalog: GCST004744 EuropePMC: 28604730 |
66,756 individuals | European |
GWAS Catalog: GCST004748 EuropePMC: 28604730 |
85,716 individuals | European |
GWAS Catalog: GCST004747 EuropePMC: 28604730 |
9,859 individuals | European |
GWAS Catalog: GCST006088 EuropePMC: 29924316 |
31,930 individuals | European |
GWAS Catalog: GCST006087 EuropePMC: 29924316 |
32,338 individuals | European |
GWAS Catalog: GCST006086 EuropePMC: 29924316 |
35,953 individuals | European |
GWAS Catalog: GCST004746 EuropePMC: 28604730 |
24,108 individuals | European |
GWAS Catalog: GCST002466 EuropePMC: 24880342 |
27,209 individuals | European |
GWAS Catalog: GCST000506 EuropePMC: 19836008 |
11,587 individuals | European |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|
PheCode:165.1; ICD9CM:162.0, 162.2, 162.3, 162.4, 162.5, 162.8, 162.9, 209.21, 231.2, V10.11; ICD10CM:C33, C34, C34.0, C34.00, C34.01, C34.02, C34.1, C34.10, C34.11, C34.12, C34.2, C34.3, C34.30, C34.31, C34.32, C34.8, C34.80, C34.81, C34.82, C34.9, C34.90, C34.91, C34.92, C7A.090, D02.2, D02.20, D02.21, D02.22 | — | [
|
— | European | — | MGI | — |
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM001074 | PSS000541 | PGP000118 Fritsche LG et al. (2020) |
Reported Trait: Cancer of bronchus; lung | OR: 1.11 [1.006, 1.225] β: 0.105 (0.0501) |
AUROC: 0.52 [0.492, 0.547] | Nagelkerke's Pseudo-R²: 0.00202 Brier score: 0.0827 Odds Ratio (OR, top 1% vs. Rest): 2.19 [1.07, 4.49] |
age, sex, batch PCs 1-4 | Cancer PRSweb PheWAS Results: PRSWEB_PHECODE165.1_GWAS-Catalog-r2019-05-03-X165.1_P_5e-08_MGI_20200608 |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000541 | PheCode:165.1; ICD9CM:162.0, 162.2, 162.3, 162.4, 162.5, 162.8, 162.9, 209.21, 231.2, V10.11; ICD10CM:C33, C34, C34.0, C34.00, C34.01, C34.02, C34.1, C34.10, C34.11, C34.12, C34.2, C34.3, C34.30, C34.31, C34.32, C34.8, C34.80, C34.81, C34.82, C34.9, C34.90, C34.91, C34.92, C7A.090, D02.2, D02.20, D02.21, D02.22 | — | [
|
— | European | — | MGI | — |