Predicted Trait | |
Reported Trait | Melanomas of skin (diagnosis or history) |
Mapped Trait(s) | melanoma (EFO_0000756) |
Additional Trait Information | PheCode 172.1 |
Score Construction | |
PGS Name | PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-08_UKB_20200608 |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 20 |
Development Method | |
Name | GWAS Hits |
Parameters | LD Clumping (MAF >= 1%, r^2 <= 0.1) & P<=5e-08 |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000118 |
Citation (link to publication) | Fritsche LG et al. Am J Hum Genet (2020) |
Study Identifiers | Sample Numbers | Sample Ancestry |
---|---|---|
EuropePMC: 28212542 | [
|
European |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|
PheCode:172.1; ICD9:-; ICD10:C43.0, C43.1, C43.2, C43.3, C43.4, C43.5, C43.6, C43.7, C43.8, C43.9, D03.0, D03.1, D03.2, D03.3, D03.4, D03.5, D03.6, D03.7, D03.8, D03.9 | — | [
|
— | European | — | UKB | — |
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM001111 | PSS000567 | PGP000118 Fritsche LG et al. (2020) |
Reported Trait: Melanomas of skin, dx or hx | OR: 1.551 [1.463, 1.643] β: 0.439 (0.0296) |
AUROC: 0.62 [0.604, 0.635] | Nagelkerke's Pseudo-R²: 0.0335 Brier score: 0.0813 Odds Ratio (OR, top 1% vs. Rest): 2.81 [1.93, 4.07] |
age, sex, batch PCs 1-4 | Cancer PRSweb PheWAS Results: PRSWEB_PHECODE172.1_Melanoma-Ransohoff_P_5e-08_UKB_20200608 |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000567 | PheCode:172.1; ICD9:-; ICD10:C43.0, C43.1, C43.2, C43.3, C43.4, C43.5, C43.6, C43.7, C43.8, C43.9, D03.0, D03.1, D03.2, D03.3, D03.4, D03.5, D03.6, D03.7, D03.8, D03.9 | — | [
|
— | European | — | UKB | — |