Predicted Trait | |
Reported Trait | Cancer of prostate |
Mapped Trait(s) | prostate carcinoma (EFO_0001663) |
Additional Trait Information | PheCode 185 |
Score Construction | |
PGS Name | PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PRS-CS_MGI_20200608 |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 1,119,236 |
Development Method | |
Name | PRS-CS |
Parameters | Parameters = auto; LD reference (eur) |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000118 |
Citation (link to publication) | Fritsche LG et al. Am J Hum Genet (2020) |
Study Identifiers | Sample Numbers | Sample Ancestry |
---|---|---|
EuropePMC: 32424355 | [
|
European |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|
PheCode:185; ICD9CM:185, 233.4, V10.46; ICD10CM:C61, D07.5 | — | [
|
— | European | — | MGI | — |
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM001275 | PSS000552 | PGP000118 Fritsche LG et al. (2020) | Reported Trait: Cancer of prostate | OR: 1.516 [1.415, 1.624] β: 0.416 (0.0353) |
AUROC: 0.614 [0.595, 0.633] | Nagelkerke's Pseudo-R²: 0.0395 Brier score: 0.15 Odds Ratio (OR, top 1% vs. Rest): 2.32 [1.42, 3.78] |
age, sex, batch PCs 1-4 | Cancer PRSweb PheWAS Results: PRSWEB_PHECODE185_UKBB-SAIGE-HRC-X185_PRS-CS_MGI_20200608 |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000552 | PheCode:185; ICD9CM:185, 233.4, V10.46; ICD10CM:C61, D07.5 | — | [
|
— | European | — | MGI | — |