Polygenic Score (PGS) ID: PGS000665

Predicted Trait
Reported Trait Ischemic stroke
Mapped Trait(s)
Released in PGS Catalog: Jan. 7, 2021
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GRS_32
Development Method
Name Genome-wide significant variants
Parameters NR
Variants
Original Genome Build NR
Number of Variants 32
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000125
Citation (link to publication) Marston NA et al. Circulation (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 85.2%
East Asian: 8.7%
African: 3.9%
South Asian: 1.7%
Hispanic or Latin American: 0.3%
Additional Asian Ancestries: 0.1%
524,354 individuals (100%)
PGS Evaluation
European: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST005838
Europe PMC: 29531354
 698 individuals Asian unspecified 62 cohorts
  • 3C
  • ,ADHD
  • ,AGES
  • ,ASGC
  • ,BASICMAR
  • ,BBJ
  • ,BRAINS
  • ,CADISP
  • ,CHS
  • ,DNA_Lacunar
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,Finland
  • ,GCNKSS
  • ,GEOS
  • ,GRAZ
  • ,Glasgow
  • ,HCHS
  • ,HISAYAMA
  • ,HPS
  • ,HRS
  • ,HVH
  • ,HealthABC
  • ,ICH
  • ,INMA
  • ,INTERSTROKE
  • ,ISGS
  • ,KORA
  • ,KRAKOW
  • ,LSGS
  • ,LSR
  • ,MCISS
  • ,MDC
  • ,MESA
  • ,MGH-GASROS
  • ,MIAMISR
  • ,MILANO
  • ,MONICA
  • ,NHS
  • ,NOMAS
  • ,OAI
  • ,PROSPER
  • ,RACE
  • ,REGARDS
  • ,RS
  • ,SAHLSIS
  • ,SDS
  • ,SHIP
  • ,SIFAP
  • ,SLESS
  • ,SOL
  • ,SPS3
  • ,SWISS
  • ,TwinGene
  • ,ULSAM
  • ,VISP
  • ,WGHS
  • ,WHI
  • ,WTCCC
  • ,WUSTL
  • ,deCODE
GWAS Catalog: GCST005838
Europe PMC: 29531354
 20,695 individuals African American or Afro-Caribbean 62 cohorts
  • 3C
  • ,ADHD
  • ,AGES
  • ,ASGC
  • ,BASICMAR
  • ,BBJ
  • ,BRAINS
  • ,CADISP
  • ,CHS
  • ,DNA_Lacunar
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,Finland
  • ,GCNKSS
  • ,GEOS
  • ,GRAZ
  • ,Glasgow
  • ,HCHS
  • ,HISAYAMA
  • ,HPS
  • ,HRS
  • ,HVH
  • ,HealthABC
  • ,ICH
  • ,INMA
  • ,INTERSTROKE
  • ,ISGS
  • ,KORA
  • ,KRAKOW
  • ,LSGS
  • ,LSR
  • ,MCISS
  • ,MDC
  • ,MESA
  • ,MGH-GASROS
  • ,MIAMISR
  • ,MILANO
  • ,MONICA
  • ,NHS
  • ,NOMAS
  • ,OAI
  • ,PROSPER
  • ,RACE
  • ,REGARDS
  • ,RS
  • ,SAHLSIS
  • ,SDS
  • ,SHIP
  • ,SIFAP
  • ,SLESS
  • ,SOL
  • ,SPS3
  • ,SWISS
  • ,TwinGene
  • ,ULSAM
  • ,VISP
  • ,WGHS
  • ,WHI
  • ,WTCCC
  • ,WUSTL
  • ,deCODE
GWAS Catalog: GCST005838
Europe PMC: 29531354
 9,144 individuals South Asian 62 cohorts
  • 3C
  • ,ADHD
  • ,AGES
  • ,ASGC
  • ,BASICMAR
  • ,BBJ
  • ,BRAINS
  • ,CADISP
  • ,CHS
  • ,DNA_Lacunar
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,Finland
  • ,GCNKSS
  • ,GEOS
  • ,GRAZ
  • ,Glasgow
  • ,HCHS
  • ,HISAYAMA
  • ,HPS
  • ,HRS
  • ,HVH
  • ,HealthABC
  • ,ICH
  • ,INMA
  • ,INTERSTROKE
  • ,ISGS
  • ,KORA
  • ,KRAKOW
  • ,LSGS
  • ,LSR
  • ,MCISS
  • ,MDC
  • ,MESA
  • ,MGH-GASROS
  • ,MIAMISR
  • ,MILANO
  • ,MONICA
  • ,NHS
  • ,NOMAS
  • ,OAI
  • ,PROSPER
  • ,RACE
  • ,REGARDS
  • ,RS
  • ,SAHLSIS
  • ,SDS
  • ,SHIP
  • ,SIFAP
  • ,SLESS
  • ,SOL
  • ,SPS3
  • ,SWISS
  • ,TwinGene
  • ,ULSAM
  • ,VISP
  • ,WGHS
  • ,WHI
  • ,WTCCC
  • ,WUSTL
  • ,deCODE
GWAS Catalog: GCST005838
Europe PMC: 29531354
 446,696 individuals European 62 cohorts
  • 3C
  • ,ADHD
  • ,AGES
  • ,ASGC
  • ,BASICMAR
  • ,BBJ
  • ,BRAINS
  • ,CADISP
  • ,CHS
  • ,DNA_Lacunar
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,Finland
  • ,GCNKSS
  • ,GEOS
  • ,GRAZ
  • ,Glasgow
  • ,HCHS
  • ,HISAYAMA
  • ,HPS
  • ,HRS
  • ,HVH
  • ,HealthABC
  • ,ICH
  • ,INMA
  • ,INTERSTROKE
  • ,ISGS
  • ,KORA
  • ,KRAKOW
  • ,LSGS
  • ,LSR
  • ,MCISS
  • ,MDC
  • ,MESA
  • ,MGH-GASROS
  • ,MIAMISR
  • ,MILANO
  • ,MONICA
  • ,NHS
  • ,NOMAS
  • ,OAI
  • ,PROSPER
  • ,RACE
  • ,REGARDS
  • ,RS
  • ,SAHLSIS
  • ,SDS
  • ,SHIP
  • ,SIFAP
  • ,SLESS
  • ,SOL
  • ,SPS3
  • ,SWISS
  • ,TwinGene
  • ,ULSAM
  • ,VISP
  • ,WGHS
  • ,WHI
  • ,WTCCC
  • ,WUSTL
  • ,deCODE
GWAS Catalog: GCST005838
Europe PMC: 29531354
 45,564 individuals East Asian 62 cohorts
  • 3C
  • ,ADHD
  • ,AGES
  • ,ASGC
  • ,BASICMAR
  • ,BBJ
  • ,BRAINS
  • ,CADISP
  • ,CHS
  • ,DNA_Lacunar
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,Finland
  • ,GCNKSS
  • ,GEOS
  • ,GRAZ
  • ,Glasgow
  • ,HCHS
  • ,HISAYAMA
  • ,HPS
  • ,HRS
  • ,HVH
  • ,HealthABC
  • ,ICH
  • ,INMA
  • ,INTERSTROKE
  • ,ISGS
  • ,KORA
  • ,KRAKOW
  • ,LSGS
  • ,LSR
  • ,MCISS
  • ,MDC
  • ,MESA
  • ,MGH-GASROS
  • ,MIAMISR
  • ,MILANO
  • ,MONICA
  • ,NHS
  • ,NOMAS
  • ,OAI
  • ,PROSPER
  • ,RACE
  • ,REGARDS
  • ,RS
  • ,SAHLSIS
  • ,SDS
  • ,SHIP
  • ,SIFAP
  • ,SLESS
  • ,SOL
  • ,SPS3
  • ,SWISS
  • ,TwinGene
  • ,ULSAM
  • ,VISP
  • ,WGHS
  • ,WHI
  • ,WTCCC
  • ,WUSTL
  • ,deCODE
GWAS Catalog: GCST005838
Europe PMC: 29531354
 1,557 individuals Hispanic or Latin American 62 cohorts
  • 3C
  • ,ADHD
  • ,AGES
  • ,ASGC
  • ,BASICMAR
  • ,BBJ
  • ,BRAINS
  • ,CADISP
  • ,CHS
  • ,DNA_Lacunar
  • ,EPIC_CAD
  • ,FHS
  • ,FINRISK
  • ,Finland
  • ,GCNKSS
  • ,GEOS
  • ,GRAZ
  • ,Glasgow
  • ,HCHS
  • ,HISAYAMA
  • ,HPS
  • ,HRS
  • ,HVH
  • ,HealthABC
  • ,ICH
  • ,INMA
  • ,INTERSTROKE
  • ,ISGS
  • ,KORA
  • ,KRAKOW
  • ,LSGS
  • ,LSR
  • ,MCISS
  • ,MDC
  • ,MESA
  • ,MGH-GASROS
  • ,MIAMISR
  • ,MILANO
  • ,MONICA
  • ,NHS
  • ,NOMAS
  • ,OAI
  • ,PROSPER
  • ,RACE
  • ,REGARDS
  • ,RS
  • ,SAHLSIS
  • ,SDS
  • ,SHIP
  • ,SIFAP
  • ,SLESS
  • ,SOL
  • ,SPS3
  • ,SWISS
  • ,TwinGene
  • ,ULSAM
  • ,VISP
  • ,WGHS
  • ,WHI
  • ,WTCCC
  • ,WUSTL
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001373 PSS000602|
European Ancestry|
51,288 individuals
 PGP000125 |
Marston NA et al. Circulation (2020)
 Reported Trait: Incident ischemic stroke — — Hazard Ratio (HR, top vs. bottom tertile): 1.24 [1.05, 1.45]
Hazard Ratio (HR, intermediate vs. bottom tertile): 1.15 [0.98, 1.36]		 age, sex, PCs(1-5), hypertension, hyperlipidemia, diabetes mellitus, smoking, bascular disease, congestive heart failure, atrial fibrillation —
PPM001374 PSS000602|
European Ancestry|
51,288 individuals
 PGP000125 |
Marston NA et al. Circulation (2020)
 Reported Trait: Incident ischemic stroke — C-index: 0.65 [0.63, 0.66] — Clinical variables from the Revised Framingham Stroke Risk score, geographic region —
PPM001375 PSS000601|
European Ancestry|
11,187 individuals
 PGP000125 |
Marston NA et al. Circulation (2020)
 Reported Trait: Incident ischemic stroke in individuals with atrial fibrillation — — Hazard Ratio (HR, top vs. bottom tertile): 1.29 [1.01, 1.64] age, sex, PCs(1-5), hypertension, hyperlipidemia, diabetes mellitus, smoking, bascular disease, congestive heart failure, atrial fibrillation, components of CHA2DS2-VASc score —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000602 The endpoint of interest was ischemic stroke. In each trial, ischemic stroke was formally adjudicated by an independent clinical endpoint committee blinded to treatment assignment. Median = 2.5 years
[
  • 960 cases
  • , 50,328 controls
]
,
71.7 % Male samples
 Mean = 65.9 years
Sd = 9.2 years		 European — ENGAGE_AF-TIMI_48, FOURIER, PEGASUS-TIMI_54, SAVOR-TIMI_53, SOLID-TIMI_52 —
PSS000601 All patients with atrial fibrillation and CHADS2 score of 2 or higher who were treated with anticoagulation. The endpoint of interest was ischemic stroke. In each trial, ischemic stroke was formally adjudicated by an independent clinical endpoint committee blinded to treatment assignment. Median = 2.8 years
[
  • 395 cases
  • , 10,792 controls
]
,
60.78 % Male samples
 Mean = 70.8 years
Sd = 9.1 years		 European — ENGAGE_AF-TIMI_48 —