PGS Catalog - PGS000673 / Aspartate aminotransferase [U/L] (Polygenic Score)

Polygenic Score (PGS) ID: PGS000673

Predicted Trait
Reported Trait	Aspartate aminotransferase [U/L]
Mapped Trait(s)	aspartate aminotransferase measurement (EFO_0004736)

Released in PGS Catalog: Feb. 3, 2021

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Terms and Licenses

Creative Commons Attribution 4.0 International (CC BY 4.0)

Score Details

Score Construction
PGS Name	snpnet.Aspartate_aminotransferase
Variants
Original Genome Build	hg19
Number of Variants	12,829
Development Method
Name	snpnet
Parameters	1,080,968 variants as input (directly genotyped variants, imputed HLA allelotypes, and CNVs)

PGS Source
PGS Catalog Publication (PGP) ID	PGP000128
Citation (link to publication)	Sinnott-Armstrong N et al. Nat Genet (2021)

Contributing Samples

Score Development/Training

Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
—	—	223,327 individuals	—	European (British)	—	UKB	Training
—	—	31,929 individuals	—	European (British)	—	UKB	Validation

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM ID)	PGS Sample Set ID (PSS ID)	Performance Source	Trait	PGS Effect Sizes (per SD change)	PGS Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM001471	PSS000649	PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021)	Reported Trait: Aspartate aminotransferase [U/L]	—	—	R²: 0.1564 Spearman's ρ: 0.278	Age, sex, PCs(1-40)	—
PPM001541	PSS000651	PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021)	Reported Trait: Aspartate aminotransferase [U/L]	—	—	R²: 0.1493 Spearman's ρ: 0.285	Age, sex, PCs(1-40)	—
PPM001506	PSS000650	PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021)	Reported Trait: Aspartate aminotransferase [U/L]	—	—	R²: 0.11262 Spearman's ρ: 0.243	Age, sex, PCs(1-40)	—
PPM001436	PSS000648	PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021)	Reported Trait: Aspartate aminotransferase [U/L]	—	—	R²: 0.08343 Spearman's ρ: 0.191	Age, sex, PCs(1-40)	—
PPM001401	PSS000647	PGP000128 Sinnott-Armstrong N et al. Nat Genet (2021)	Reported Trait: Aspartate aminotransferase [U/L]	—	—	R²: 0.10334 Spearman's ρ: 0.103	Age, sex, PCs(1-40)	—

Evaluated Samples

PGS Sample Set ID (PSS ID)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS000647	—	—	5,982 individuals	—	African unspecified	—	UKB	—
PSS000648	—	—	1,070 individuals	—	East Asian	—	UKB	—
PSS000649	—	—	23,483 individuals	—	European	Non-British White	UKB	—
PSS000650	—	—	7,313 individuals	—	South Asian	—	UKB	—
PSS000651	—	—	63,562 individuals	—	European (British)	—	UKB	—