Polygenic Score (PGS) ID: PGS000673

Predicted Trait
Reported Trait Aspartate aminotransferase [U/L]
Mapped Trait(s) aspartate aminotransferase measurement (EFO_0004736)
Released in PGS Catalog: Feb. 3, 2021
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Terms and Licenses
Creative Commons Attribution 4.0 International (CC BY 4.0)

Score Details

Score Construction
PGS Name snpnet.Aspartate_aminotransferase
Variants
Original Genome Build hg19
Number of Variants 12,829
Development Method
Name snpnet
Parameters 1,080,968 variants as input (directly genotyped variants, imputed HLA allelotypes, and CNVs)
PGS Source
PGS Catalog Publication (PGP) ID PGP000128
Citation (link to publication) Sinnott-Armstrong N et al. Nat Genet (2021)

Contributing Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
223,327 individuals European
(British)
UKB Training
31,929 individuals European
(British)
UKB Validation

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001471 PSS000649 PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Aspartate aminotransferase [U/L] : 0.1564
Spearman's ρ: 0.278
Age, sex, PCs(1-40)
PPM001541 PSS000651 PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Aspartate aminotransferase [U/L] : 0.1493
Spearman's ρ: 0.285
Age, sex, PCs(1-40)
PPM001506 PSS000650 PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Aspartate aminotransferase [U/L] : 0.11262
Spearman's ρ: 0.243
Age, sex, PCs(1-40)
PPM001436 PSS000648 PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Aspartate aminotransferase [U/L] : 0.08343
Spearman's ρ: 0.191
Age, sex, PCs(1-40)
PPM001401 PSS000647 PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: Aspartate aminotransferase [U/L] : 0.10334
Spearman's ρ: 0.103
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000647 5,982 individuals African unspecified UKB
PSS000648 1,070 individuals East Asian UKB
PSS000649 23,483 individuals European Non-British White UKB
PSS000650 7,313 individuals South Asian UKB
PSS000651 63,562 individuals European
(British)
UKB