Polygenic Score (PGS) ID: PGS000687

Predicted Trait
Reported Trait IGF-1 [nmol/L]
Mapped Trait(s) IGF-1 measurement (EFO_0004627)
Released in PGS Catalog: Feb. 3, 2021
Download Score FTP directory
Terms and Licenses
Creative Commons Attribution 4.0 International (CC BY 4.0)

Score Details

Score Construction
PGS Name snpnet.IGF_1
Variants
Original Genome Build hg19
Number of Variants 23,443
Development Method
Name snpnet
Parameters 1,080,968 variants as input (directly genotyped variants, imputed HLA allelotypes, and CNVs)
PGS Source
PGS Catalog Publication (PGP) ID PGP000128
Citation (link to publication) Sinnott-Armstrong N et al. Nat Genet (2021)

Contributing Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
223,327 individuals European
(British)
UKB Training
31,929 individuals European
(British)
UKB Validation

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001555 PSS000713 PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: IGF-1 [nmol/L] : 0.20434
Spearman's ρ: 0.369
Age, sex, PCs(1-40)
PPM001520 PSS000712 PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: IGF-1 [nmol/L] : 0.20212
Spearman's ρ: 0.313
Age, sex, PCs(1-40)
PPM001485 PSS000711 PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: IGF-1 [nmol/L] : 0.22328
Spearman's ρ: 0.362
Age, sex, PCs(1-40)
PPM001450 PSS000710 PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: IGF-1 [nmol/L] : 0.17702
Spearman's ρ: 0.258
Age, sex, PCs(1-40)
PPM001415 PSS000709 PGP000128
Sinnott-Armstrong N et al. Nat Genet (2021)
Reported Trait: IGF-1 [nmol/L] : 0.11454
Spearman's ρ: 0.182
Age, sex, PCs(1-40)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000711 23,453 individuals European Non-British White UKB
PSS000712 7,283 individuals South Asian UKB
PSS000713 63,393 individuals European
(British)
UKB
PSS000709 5,974 individuals African unspecified UKB
PSS000710 1,074 individuals East Asian UKB