Polygenic Score (PGS) ID: PGS000714

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: Feb. 3, 2021
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Score Details

Score Construction
PGS Name PRS55_PC
Variants
Original Genome Build NR
Number of Variants 55
Development Method
Name Genome-wide significant SNPs
Parameters p<5e-8, ORs <1.1 or >0.9
PGS Source
PGS Catalog Publication (PGP) ID PGP000130
Citation (link to publication) Sipeky C et al. Sci Rep (2020)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST001942
EuropePMC: 23535732
22,548 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001624 PSS000840 PGP000130
Sipeky C et al. Sci Rep (2020)
Reported Trait: Prostate cancer OR: 2.13 [1.9, 2.39] AUROC: 0.618 [0.6, 0.63]
PPM001625 PSS000841 PGP000130
Sipeky C et al. Sci Rep (2020)
Reported Trait: Prostate cancer (clinical cases) OR: 2.18 [1.93, 2.45] AUROC: 0.622 [0.61, 0.64]
PPM001626 PSS000843 PGP000130
Sipeky C et al. Sci Rep (2020)
Reported Trait: Prostate cancer (screening trial detected) OR: 1.92 [1.56, 2.37] AUROC: 0.597 [0.57, 0.63]
PPM001627 PSS000842 PGP000130
Sipeky C et al. Sci Rep (2020)
Reported Trait: Metastatic prostate cancer OR: 1.47 AUROC: 0.549

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000840 Cases: clinically diagnosed or screen-detected prostate cancer. Controls: free of cancer
[
  • 2,738 cases
  • , 2,400 controls
]
,
100.0 % Male samples
European
(Finnish)
FinRSPC, PHD
PSS000841 Cases: clinically diagnosed with prostate cancer. Controls: free of cancer.
[
  • 2,283 cases
  • , 2,400 controls
]
,
100.0 % Male samples
European
(Finnish)
FinRSPC, PHD
PSS000842
[
  • 191 cases
  • , 2,400 controls
]
,
100.0 % Male samples
European
(Finnish)
FinRSPC, PHD
PSS000843 Cases: screen-detected prostate cancer. Controls: free of cancer.
[
  • 455 cases
  • , 2,400 controls
]
,
100.0 % Male samples
European
(Finnish)
FinRSPC