Polygenic Score (PGS) ID: PGS000718

Predicted Trait
Reported Trait Beta-blocker survival benefit
Mapped Trait(s) response to beta blocker (EFO_0007766)
Released in PGS Catalog: Feb. 3, 2021
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Score Details

Score Construction
PGS Name PRPBB_44
Variants
Original Genome Build GRCh37
Number of Variants 44
Development Method
Name Cox proportional hazard model + LD-clumping
Parameters Model: Death~Meta-Analysis Global Group in Chronic Heart Failure score+beta blocker propensity+beta blocker exposure+SNP+SNPxbeta blocker exposure
PGS Source
PGS Catalog Publication (PGP) ID PGP000134
Citation (link to publication) Lanfear DE et al. Circ Heart Fail (2020)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST010923
EuropePMC: 33012170
248 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001643 PSS000852 PGP000134
Lanfear DE et al. Circ Heart Fail (2020)
Reported Trait: Response to beta blocker (reduction in cardiovascular death) in heart failure patients P-value (treatment benefit in low vs. high PRP patients): 0.046 Meta-Analysis Global Group in Chronic Heart Failure Score, beta-blocker propensity score Low polygenic response predictor score < 30th percentile of derviation group
PPM001642 PSS000851 PGP000134
Lanfear DE et al. Circ Heart Fail (2020)
Reported Trait: Response to beta blocker (reduction in all-cause mortality) in heart failure patients P-value (treatment benefit in low vs. high PRP patients): 0.024 Meta-Analysis Global Group in Chronic Heart Failure Score, beta-blocker propensity score Low polygenic response predictor score < 30th percentile of derviation group

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000851 Cases = number of cardiovascular deathsHFPGR: Patients with left ventricular ejection fraction (LVEF) <50% were included. Beta-blocker (BB) exposure was calculated from pharmacy claims (ie, drug actually dispensed to patient) and was updated over time. Beta-blocker (BB) exposure was calculated from pharmacy claims (ie, drug actually dispensed to patient) and was updated over time. TIME-CHF: Patients with analysable data and a baseline LVEF <50% were included. BB exposure was calculated from the specific drug and dose at baseline, using the same dose-equivalence scheme as HFPGR but implemented without any updates over time and without information on medication dispensing (ie, assumes patients were receiving the dose prescribed). HF-ACTION: BB exposure was calculated from the specific drug and dose at baseline, using the same dose-equivalence scheme as HFPGR but implemented without any updates over time and without information on medication dispensing (ie, assumes patients were receiving the dose prescribed).
[
  • 200 cases
  • , 988 controls
]
European HF-ACTION, HFPGR, TIME-CHF
PSS000852 Cases = number of all cause deaths. HFPGR: Patients with left ventricular ejection fraction (LVEF) <50% were included. Beta-blocker (BB) exposure was calculated from pharmacy claims (ie, drug actually dispensed to patient) and was updated over time. Beta-blocker (BB) exposure was calculated from pharmacy claims (ie, drug actually dispensed to patient) and was updated over time. TIME-CHF: Patients with analysable data and a baseline LVEF <50% were included. BB exposure was calculated from the specific drug and dose at baseline, using the same dose-equivalence scheme as HFPGR but implemented without any updates over time and without information on medication dispensing (ie, assumes patients were receiving the dose prescribed). HF-ACTION: BB exposure was calculated from the specific drug and dose at baseline, using the same dose-equivalence scheme as HFPGR but implemented without any updates over time and without information on medication dispensing (ie, assumes patients were receiving the dose prescribed).
[
  • 279 cases
  • , 909 controls
]
European HF-ACTION, HFPGR, TIME-CHF