Polygenic Score (PGS) ID: PGS000722

Predicted Trait
Reported Trait Kidney cancer
Mapped Trait(s) renal carcinoma (EFO_0002890)
Released in PGS Catalog: Feb. 3, 2021
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Score Details

Score Construction
PGS Name PRS_Kidney
Variants
Original Genome Build hg19
Number of Variants 15
Development Method
Name Genome-wide significant SNPs
Parameters NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000135
Citation (link to publication) Jia G et al. JNCI Cancer Spectr (2020)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST004710
EuropePMC: 28598434
31,190 individuals European
GWAS Catalog: GCST002835
EuropePMC: 25826619
10,871 individuals European
GWAS Catalog: GCST000907
EuropePMC: 21131975
12,277 individuals European
EuropePMC: 22113997.0
[
  • 2,278 cases
  • , 3,719 controls
]
European
GWAS Catalog: GCST001750
EuropePMC: 23184150
10,781 individuals European
GWAS Catalog: GCST002273
EuropePMC: 24220699
69,230 individuals European
GWAS Catalog: GCST001283
EuropePMC: 22010048
2,410 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001652 PSS000856 PGP000135
Jia G et al. JNCI Cancer Spectr (2020)
Reported Trait: Incident kidney cancer AUROC: 0.567 [0.543, 0.591] Genotyping array

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000856 Data and diagnoses on site-specific incident cancers were provided by the National Health Service Information Centre for participants from England and Wales (follow-up through March 31, 2016) and by the NHS Central Register Scotland for participants from Scotland (follow-up through October 31, 2015). Cancers were coded by the International Classification of Diseases, Ninth Revision (ICD-9) or the International Classification of Diseases, Tenth Revision (ICD-10). Kidney Cancer=(ICD-9 = 189.0 or ICD-10 = C64) Median = 5.8 years
[
  • 545 cases
  • , 400,267 controls
]
,
46.5 % Male samples
European UKB