Predicted Trait | |
Reported Trait | Squamous cell carcinoma |
Mapped Trait(s) | squamous cell carcinoma (EFO_0000707) |
Score Construction | |
PGS Name | PRS_SCC |
Variants | |
Original Genome Build | hg19 |
Number of Variants | 14 |
Development Method | |
Name | RiskPipe (clumping and thresholding) |
Parameters | p<1e-6 |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000138 |
Citation (link to publication) | Fontanillas P et al. Nat Commun (2021) |
Study Identifiers | Sample Numbers | Sample Ancestry |
---|---|---|
EuropePMC: 33420020.0 | [ ,
42.6 % Male samples |
European |
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM001671 | PSS000873 | PGP000138 Fontanillas P et al. Nat Commun (2021) |
Reported Trait: Squamous cell carcinoma | OR: 1.44 [1.41, 1.48] | AUROC: 0.605 | — | — | — |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000873 | Squamous cell carcinoma cases were determined by a baseline survey containing 34 questions regarding personal history of skin cancer(including skin cancer type, age at diagnosis, body location, prescribed treatments and information regarding cancer recurrence) | — | [ ,
38.9 % Male samples |
European | — | 23andMe | — |