Polygenic Score (PGS) ID: PGS000763

Predicted Trait
Reported Trait Hearing aid use
Mapped Trait(s) age-related hearing impairment (EFO_0005782)
Released in PGS Catalog: April 28, 2021
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Score Details

Disclaimer: The original published polygenic score is unavailable. The authors have provided an alternative polygenic for the Catalog. Please note some details and performance metrics may differ from the publication.
Score Construction
PGS Name PRS_HAID
Development Method
Name PRSice
Parameters INFO: 0.9, MAF: 0.01, clump-r2: 0.1, p<0.0056; software version = 2.1.3.beta
Variants
Original Genome Build hg19
Number of Variants 4,270
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000165
Citation (link to publication) Cherny SS et al. Eur J Hum Genet (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
253,918 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST008898
Europe PMC: 31564434
 253,918 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM001937 PSS000971|
European Ancestry|
2,912 individuals
 PGP000165 |
Cherny SS et al. Eur J Hum Genet (2020)
 Reported Trait: Hearing aid use — — R²: 0.1923 Age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000971 Hearing aid use cases responded ‘Yes’ to either ‘Do you wear a hearing aid?’ or ‘Wearing a hearing aid’ while controls responded ‘No’. —
[
  • 216 cases
  • , 2,696 controls
]
,
8.0 % Male samples
 Mean = 59.32 years
Sd = 9.69 years		 European
(British)		 — TwinsUK —