Polygenic Score (PGS) ID: PGS000911

Predicted Trait
Reported Trait Ischemic stroke
Mapped Trait(s)
Released in PGS Catalog: Oct. 7, 2021
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS_IS
Development Method
Name lassosum
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 530,933
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000239
Citation (link to publication) O'Sullivan JW et al. Circ Genom Precis Med (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
446,696 individuals (100%)
Score Development/Training
European: 100%
566 individuals (100%)
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006906
Europe PMC: 29531354
 446,696 individuals European 11 cohorts
  • CADISP
  • ,CHARGE
  • ,DNA_Lacunar
  • ,EPIC
  • ,ICH
  • ,INTERSTROKE
  • ,MDC
  • ,SAHLSIS
  • ,SIFAP
  • ,SiGN
  • ,deCODE
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 566 individuals European UKB Sample consisted of individuals with prevalent atrial fibrillation prior to enrollment. — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002960 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases OR: 1.14 [1.06, 1.23] — — Age at recruitment, sex, UK Biobank array type, PCs(1-10) —
PPM002961 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases OR: 1.14 [1.06, 1.23] AUROC: 0.605 [0.583, 0.626] — Age at recruitment, sex, UK Biobank array type, PCs(1-10), presence of warfarin prescription —
PPM002962 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases who had not been prescribed warfarin OR: 1.14 [1.05, 1.24] — — Age at recruitment, sex, UK Biobank array type, PCs(1-10) —
PPM002963 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases OR: 1.14 [1.06, 1.23] — — Age at recruitment, sex, UK Biobank array type, PCs(1-10), cumulative CHA2DS2-VASc score —
PPM002964 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases OR: 1.14 — — Age at recruitment, sex, UK Biobank array type, PCs(1-10), individual components of CHA2DS2-VASc score —
PPM002965 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases HR: 1.13 [1.04, 1.21] C-index: 0.56 [0.54, 0.58] — Sex, UK Biobank array, PCs(1-10) —
PPM002966 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases HR: 1.14 [1.01, 1.23] C-index: 0.56 [0.54, 0.58] — Sex, age, UK Biobank array, PCs(1-10) —
PPM002967 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases who had not been prescribed warfarin HR: 1.13 [1.04, 1.22] C-index: 0.57 [0.54, 0.59] — Sex, UK Biobank array, PCs(1-10) —
PPM002968 PSS001445|
European Ancestry|
15,929 individuals
 PGP000239 |
O'Sullivan JW et al. Circ Genom Precis Med (2021)
 Reported Trait: Ischemic stroke in atrial fibrillation cases — C-index: 0.61 [0.58, 0.63] — Sex, UK Biobank array, PCs(1-10), cumulative CHA2DS2-VASc score —
PPM021351 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident heart failure HR: 1.08 [1.06, 1.1] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —
PPM021348 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Cardiovascular death, stroke, hospitalization for worsening of HF, or acute coronary syndrome HR: 1.13 [1.0, 1.27] — — Treatment group —
PPM021349 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Stroke HR: 1.0 [0.75, 1.34] — — Treatment group —
PPM021350 PSS011698|
European Ancestry|
1,567 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Worsening of heart failure HR: 1.23 [1.05, 1.43] — — Treatment group —
PPM021352 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident stroke HR: 1.08 [1.06, 1.11] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —
PPM021353 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident ischemic stroke HR: 1.11 [1.08, 1.14] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —
PPM021354 PSS011699|
European Ancestry|
407,311 individuals
 PGP000637 |
Kany S et al. Cardiovasc Res (2023)
|Ext.		 Reported Trait: Incident atrial fibrillation or atrial flutter HR: 1.15 [1.14, 1.67] — — Sex, 5 PCs, genotyping array, cubic splines of age at enrolment, height, weight, BMI, systolic blood pressure, diastolic blood pressure —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001445 All individuals had a history of incident atrial fibrillation (AF) following enrollment. 2,310 individuals were taking warfarin. Cases were individuals with ischemic stroke (IS). IS was defined uisng the UKB codes: 131368, 42008. Of the 2,310 individuals taking warfarin, 93 were individuals with ischemic stroke (cases). Median = 7.0 years
[
  • 684 cases
  • , 15,245 controls
]
,
66.7 % Male samples
 European — UKB —
PSS011698 — — 1,567 individuals — European — EAST-AFNET4 —
PSS011699 — — 407,311 individuals — European — UKB —