Polygenic Score (PGS) ID: PGS000921

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: Nov. 4, 2021
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Score Details

Score Construction
PGS Name PRS_BMI
Development Method
Name LDpred
Parameters fraction of causative variants = 0.3, software version = 1.0.6
Variants
Original Genome Build GRCh37
Number of Variants 1,947,711
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000243
Citation (link to publication) Borisevich D et al. PLoS One (2021)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 67%
Not Reported: 33%
681,275 individuals (100%)
Score Development/Training
European: 100%
1,000 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006900
Europe PMC: 30124842
 224,849 individuals Not reported GIANT, UKB
GWAS Catalog: GCST006900
Europe PMC: 30124842
 456,426 individuals European GIANT, UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 1,000 individuals European
(Danish)		 Inter99 — — — — Independent subset of Inter99, doesn't overlap with validation samples

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM002993 PSS001456|
European Ancestry|
5,179 individuals
 PGP000243 |
Borisevich D et al. PLoS One (2021)
 Reported Trait: Body mass index β: 1.7 kg/m2 — R²: 0.162
R2 (linear regression BMI ~ 1 + PRS): 0.131		 age, sex —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS001456 — — 5,179 individuals — European
(Danish)		 — Inter99 Independent subset of Inter99, doesn't overlap with score development samples