Polygenic Score (PGS) ID: PGS001016

Predicted Trait
Reported Trait Sensitivity / hurt feelings
Mapped Trait(s) feeling emotionally hurt measurement (EFO_0009599)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/BIN1950
Released in PGS Catalog: Oct. 21, 2021
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_BIN1950
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 7,922
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
262,892 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 148,440 cases
  • , 114,452 controls
]
 European UKB — — — white British ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM007843 PSS003637|
African Ancestry|
6,118 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Sensitivity / hurt feelings — AUROC: 0.59163 [0.57735, 0.60591] R²: 0.0326
Incremental AUROC (full-covars): -0.01552
PGS R2 (no covariates): 7e-05
PGS AUROC (no covariates): 0.49648 [0.48187, 0.5111]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007844 PSS003638|
East Asian Ancestry|
1,534 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Sensitivity / hurt feelings — AUROC: 0.61857 [0.59048, 0.64665] R²: 0.06515
Incremental AUROC (full-covars): 0.00123
PGS R2 (no covariates): 0.00285
PGS AUROC (no covariates): 0.52442 [0.49546, 0.55337]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007845 PSS003639|
European Ancestry|
24,064 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Sensitivity / hurt feelings — AUROC: 0.60838 [0.60128, 0.61549] R²: 0.04732
Incremental AUROC (full-covars): 0.01171
PGS R2 (no covariates): 0.00998
PGS AUROC (no covariates): 0.54753 [0.54024, 0.55481]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007846 PSS003640|
South Asian Ancestry|
7,159 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Sensitivity / hurt feelings — AUROC: 0.60244 [0.58913, 0.61576] R²: 0.03988
Incremental AUROC (full-covars): 0.00657
PGS R2 (no covariates): 0.00436
PGS AUROC (no covariates): 0.53424 [0.5206, 0.54787]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method
PPM007847 PSS003641|
European Ancestry|
65,709 individuals
 PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
 Reported Trait: Sensitivity / hurt feelings — AUROC: 0.62016 [0.61586, 0.62446] R²: 0.0571
Incremental AUROC (full-covars): 0.01553
PGS R2 (no covariates): 0.00873
PGS AUROC (no covariates): 0.54593 [0.5415, 0.55036]		 age, sex, UKB array type, Genotype PCs Full Model & PGS R2 is estimated using Nagelkerke's method

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS003637 — —
[
  • 2,629 cases
  • , 3,489 controls
]
 — African unspecified — UKB —
PSS003638 — —
[
  • 681 cases
  • , 853 controls
]
 — East Asian — UKB —
PSS003639 — —
[
  • 13,147 cases
  • , 10,917 controls
]
 — European non-white British ancestry UKB —
PSS003640 — —
[
  • 4,355 cases
  • , 2,804 controls
]
 — South Asian — UKB —
PSS003641 — —
[
  • 37,128 cases
  • , 28,581 controls
]
 — European white British ancestry UKB Testing cohort (heldout set)