Polygenic Score (PGS) ID: PGS001172

Predicted Trait
Reported Trait Eosinophil count
Mapped Trait(s) eosinophil count (EFO_0004842)
Additional Trait Information https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI30150
Released in PGS Catalog: Oct. 21, 2021
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GBE_INI30150
Development Method
Name snpnet
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 12,579
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000244
Citation (link to publication) Tanigawa Y et al. PLoS Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
261,890 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
East Asian: 20%
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
261,890 individuals European UKB white British ancestry

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source Trait PGS Effect Sizes
(per SD change)
Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM008570 PSS006981|
African Ancestry|
6,120 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill count : 0.02165 [0.01465, 0.02865]
Incremental R2 (full-covars): 0.01273
PGS R2 (no covariates): 0.01483 [0.009, 0.02067]
age, sex, UKB array type, Genotype PCs
PPM008571 PSS006982|
East Asian Ancestry|
1,654 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill count : 0.07017 [0.04683, 0.09352]
Incremental R2 (full-covars): 0.02406
PGS R2 (no covariates): 0.02686 [0.01175, 0.04197]
age, sex, UKB array type, Genotype PCs
PPM008572 PSS006983|
European Ancestry|
24,129 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill count : 0.10592 [0.09869, 0.11315]
Incremental R2 (full-covars): 0.08944
PGS R2 (no covariates): 0.0939 [0.08701, 0.1008]
age, sex, UKB array type, Genotype PCs
PPM008573 PSS006984|
South Asian Ancestry|
7,491 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill count : 0.06486 [0.05432, 0.07541]
Incremental R2 (full-covars): 0.05229
PGS R2 (no covariates): 0.05348 [0.04379, 0.06318]
age, sex, UKB array type, Genotype PCs
PPM008574 PSS006985|
European Ancestry|
65,520 individuals
PGP000244 |
Tanigawa Y et al. PLoS Genet (2022)
Reported Trait: Eosinophill count : 0.10264 [0.0983, 0.10698]
Incremental R2 (full-covars): 0.09343
PGS R2 (no covariates): 0.09398 [0.08978, 0.09817]
age, sex, UKB array type, Genotype PCs

Evaluated Samples

PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS006981 6,120 individuals African unspecified UKB
PSS006982 1,654 individuals East Asian UKB
PSS006983 24,129 individuals European non-white British ancestry UKB
PSS006984 7,491 individuals South Asian UKB
PSS006985 65,520 individuals European white British ancestry UKB Testing cohort (heldout set)