Polygenic Score (PGS) ID: PGS001820

Predicted Trait
Reported Trait Hypoglycemia
Mapped Trait(s) Hypoglycemia (HP_0001943)
Additional Trait Information endocrine/metabolic
Released in PGS Catalog: Jan. 10, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name portability-PLR_251.1
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 187
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009467 PSS008843|
African Ancestry|
3,403 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): -0.0115 [-0.0452, 0.0222] sex, age, birth date, deprivation index, 16 PCs —
PPM009462 PSS008618|
European Ancestry|
6,237 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0107 [-0.0142, 0.0355] sex, age, birth date, deprivation index, 16 PCs —
PPM009463 PSS008394|
Greater Middle Eastern Ancestry|
1,092 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0024 [-0.0575, 0.0622] sex, age, birth date, deprivation index, 16 PCs —
PPM009464 PSS008172|
South Asian Ancestry|
5,103 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0157 [-0.0118, 0.0432] sex, age, birth date, deprivation index, 16 PCs —
PPM009465 PSS007959|
East Asian Ancestry|
1,714 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): -0.0258 [-0.0733, 0.0219] sex, age, birth date, deprivation index, 16 PCs —
PPM009466 PSS007740|
African Ancestry|
2,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): -0.0074 [-0.0499, 0.0351] sex, age, birth date, deprivation index, 16 PCs —
PPM009460 PSS009290|
European Ancestry|
18,689 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0286 [0.0143, 0.043] sex, age, birth date, deprivation index, 16 PCs —
PPM009461 PSS009064|
European Ancestry|
3,905 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0119 [-0.0196, 0.0433] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009064 — — 3,905 individuals — European Poland (NE Europe) UKB —
PSS008394 — — 1,092 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008618 — — 6,237 individuals — European Italy (South Europe) UKB —
PSS008172 — — 5,103 individuals — South Asian India (South Asia) UKB —
PSS008843 — — 3,403 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009290 — — 18,689 individuals — European UK (+ Ireland) UKB —
PSS007959 — — 1,714 individuals — East Asian China (East Asia) UKB —
PSS007740 — — 2,147 individuals — African American or Afro-Caribbean Carribean UKB —