Polygenic Score (PGS) ID: PGS002083

Predicted Trait
Reported Trait Psoriasis
Mapped Trait(s) psoriasis (EFO_0000676)
Additional Trait Information dermatologic
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_696.4
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 71,744
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011525 PSS009347|
European Ancestry|
19,615 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0632 [0.0493, 0.0771] sex, age, birth date, deprivation index, 16 PCs —
PPM011526 PSS009121|
European Ancestry|
4,059 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.1153 [0.0847, 0.1456] sex, age, birth date, deprivation index, 16 PCs —
PPM011527 PSS008675|
European Ancestry|
6,554 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.041 [0.0168, 0.0652] sex, age, birth date, deprivation index, 16 PCs —
PPM011529 PSS008229|
South Asian Ancestry|
6,161 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.03 [0.005, 0.055] sex, age, birth date, deprivation index, 16 PCs —
PPM011530 PSS008010|
East Asian Ancestry|
1,784 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0119 [-0.0348, 0.0585] sex, age, birth date, deprivation index, 16 PCs —
PPM011531 PSS007794|
African Ancestry|
2,398 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0375 [-0.0027, 0.0776] sex, age, birth date, deprivation index, 16 PCs —
PPM011532 PSS008898|
African Ancestry|
3,834 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): -0.0166 [-0.0483, 0.0152] sex, age, birth date, deprivation index, 16 PCs —
PPM011528 PSS008449|
Greater Middle Eastern Ancestry|
1,183 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Psoriasis — — Partial Correlation (partial-r): 0.0458 [-0.0117, 0.1031] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008229 — — 6,161 individuals — South Asian India (South Asia) UKB —
PSS009347 — — 19,615 individuals — European UK (+ Ireland) UKB —
PSS008010 — — 1,784 individuals — East Asian China (East Asia) UKB —
PSS007794 — — 2,398 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008449 — — 1,183 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009121 — — 4,059 individuals — European Poland (NE Europe) UKB —
PSS008898 — — 3,834 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008675 — — 6,554 individuals — European Italy (South Europe) UKB —