Polygenic Score (PGS) ID: PGS002099

Predicted Trait
Reported Trait Albumin
Mapped Trait(s) serum albumin amount (OBA_2050068)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_albumin
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 816,264
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011648 PSS009382|
European Ancestry|
17,457 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.289 [0.2754, 0.3026] sex, age, birth date, deprivation index, 16 PCs —
PPM011649 PSS009156|
European Ancestry|
3,593 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2771 [0.2465, 0.3071] sex, age, birth date, deprivation index, 16 PCs —
PPM011650 PSS008710|
European Ancestry|
5,803 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2717 [0.2476, 0.2954] sex, age, birth date, deprivation index, 16 PCs —
PPM011651 PSS008484|
Greater Middle Eastern Ancestry|
1,036 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2567 [0.1983, 0.3132] sex, age, birth date, deprivation index, 16 PCs —
PPM011652 PSS008262|
South Asian Ancestry|
5,478 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.265 [0.2402, 0.2895] sex, age, birth date, deprivation index, 16 PCs —
PPM011653 PSS008040|
East Asian Ancestry|
1,560 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.2305 [0.1827, 0.2773] sex, age, birth date, deprivation index, 16 PCs —
PPM011654 PSS007826|
African Ancestry|
2,159 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.1481 [0.1063, 0.1893] sex, age, birth date, deprivation index, 16 PCs —
PPM011655 PSS008930|
African Ancestry|
3,401 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Albumin — — Partial Correlation (partial-r): 0.1569 [0.1238, 0.1896] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009156 — — 3,593 individuals — European Poland (NE Europe) UKB —
PSS008484 — — 1,036 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009382 — — 17,457 individuals — European UK (+ Ireland) UKB —
PSS008710 — — 5,803 individuals — European Italy (South Europe) UKB —
PSS008262 — — 5,478 individuals — South Asian India (South Asia) UKB —
PSS008040 — — 1,560 individuals — East Asian China (East Asia) UKB —
PSS007826 — — 2,159 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008930 — — 3,401 individuals — African unspecified Nigeria (West Africa) UKB —