Polygenic Score (PGS) ID: PGS002104

Predicted Trait
Reported Trait Hearing difficulty/problems
Mapped Trait(s) hearing disorder (MONDO_0021945)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_bad_hearing
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 869,179
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011688 PSS009387|
European Ancestry|
19,161 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.1065 [0.0925, 0.1205] sex, age, birth date, deprivation index, 16 PCs —
PPM011689 PSS009161|
European Ancestry|
3,907 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0785 [0.0471, 0.1096] sex, age, birth date, deprivation index, 16 PCs —
PPM011690 PSS008715|
European Ancestry|
6,265 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0784 [0.0537, 0.103] sex, age, birth date, deprivation index, 16 PCs —
PPM011691 PSS008489|
Greater Middle Eastern Ancestry|
1,089 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0425 [-0.0175, 0.1022] sex, age, birth date, deprivation index, 16 PCs —
PPM011692 PSS008267|
South Asian Ancestry|
5,858 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0702 [0.0446, 0.0956] sex, age, birth date, deprivation index, 16 PCs —
PPM011693 PSS008045|
East Asian Ancestry|
1,684 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0612 [0.0132, 0.1089] sex, age, birth date, deprivation index, 16 PCs —
PPM011695 PSS008935|
African Ancestry|
3,691 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): 0.0136 [-0.0187, 0.046] sex, age, birth date, deprivation index, 16 PCs —
PPM011694 PSS007831|
African Ancestry|
2,325 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hearing difficulty/problems — — Partial Correlation (partial-r): -0.0054 [-0.0462, 0.0354] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008935 — — 3,691 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008489 — — 1,089 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009161 — — 3,907 individuals — European Poland (NE Europe) UKB —
PSS008267 — — 5,858 individuals — South Asian India (South Asia) UKB —
PSS008715 — — 6,265 individuals — European Italy (South Europe) UKB —
PSS009387 — — 19,161 individuals — European UK (+ Ireland) UKB —
PSS008045 — — 1,684 individuals — East Asian China (East Asia) UKB —
PSS007831 — — 2,325 individuals — African American or Afro-Caribbean Carribean UKB —