Polygenic Score (PGS) ID: PGS002111

Predicted Trait
Reported Trait Ever depressed for a whole week
Mapped Trait(s) depressive symptom measurement (EFO_0007006)
Additional Trait Information psychiatric disorders
Released in PGS Catalog: Jan. 10, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name portability-ldpred2_depressed_for_1w
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 791,873
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011743 PSS009394|
European Ancestry|
6,445 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.1053 [0.0811, 0.1295] sex, age, birth date, deprivation index, 16 PCs —
PPM011744 PSS009168|
European Ancestry|
1,519 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0816 [0.0311, 0.1317] sex, age, birth date, deprivation index, 16 PCs —
PPM011745 PSS008722|
European Ancestry|
2,506 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0665 [0.0273, 0.1055] sex, age, birth date, deprivation index, 16 PCs —
PPM011746 PSS008496|
Greater Middle Eastern Ancestry|
505 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): -0.0079 [-0.0968, 0.0812] sex, age, birth date, deprivation index, 16 PCs —
PPM011747 PSS008274|
South Asian Ancestry|
3,525 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0554 [0.0223, 0.0883] sex, age, birth date, deprivation index, 16 PCs —
PPM011748 PSS008051|
East Asian Ancestry|
751 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): -0.0086 [-0.0811, 0.064] sex, age, birth date, deprivation index, 16 PCs —
PPM011749 PSS007838|
African Ancestry|
1,457 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): 0.0277 [-0.0241, 0.0793] sex, age, birth date, deprivation index, 16 PCs —
PPM011750 PSS008942|
African Ancestry|
2,067 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever depressed for a whole week — — Partial Correlation (partial-r): -0.0201 [-0.0633, 0.0233] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008942 — — 2,067 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008496 — — 505 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009168 — — 1,519 individuals — European Poland (NE Europe) UKB —
PSS008722 — — 2,506 individuals — European Italy (South Europe) UKB —
PSS008274 — — 3,525 individuals — South Asian India (South Asia) UKB —
PSS009394 — — 6,445 individuals — European UK (+ Ireland) UKB —
PSS008051 — — 751 individuals — East Asian China (East Asia) UKB —
PSS007838 — — 1,457 individuals — African American or Afro-Caribbean Carribean UKB —