Polygenic Score (PGS) ID: PGS002124

Predicted Trait
Reported Trait Ever addicted to any substance or behaviour
Mapped Trait(s) addictive behaviour (EFO_0004347)
Additional Trait Information lifestyle and environment
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_ever_addicted
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 566,292
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011847 PSS009401|
European Ancestry|
6,380 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): 0.0328 [0.0082, 0.0573] sex, age, birth date, deprivation index, 16 PCs —
PPM011848 PSS009175|
European Ancestry|
1,218 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): 0.0465 [-0.0101, 0.1029] sex, age, birth date, deprivation index, 16 PCs —
PPM011849 PSS008729|
European Ancestry|
2,243 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): -0.0196 [-0.0611, 0.022] sex, age, birth date, deprivation index, 16 PCs —
PPM011850 PSS008503|
Greater Middle Eastern Ancestry|
203 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): 0.1801 [0.036, 0.3169] sex, age, birth date, deprivation index, 16 PCs —
PPM011851 PSS008281|
South Asian Ancestry|
811 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): -0.0084 [-0.0781, 0.0613] sex, age, birth date, deprivation index, 16 PCs —
PPM011852 PSS008058|
East Asian Ancestry|
421 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): -0.0768 [-0.1734, 0.0213] sex, age, birth date, deprivation index, 16 PCs —
PPM011853 PSS007845|
African Ancestry|
371 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): 0.0547 [-0.0503, 0.1585] sex, age, birth date, deprivation index, 16 PCs —
PPM011854 PSS008949|
African Ancestry|
513 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ever addicted to any substance or behaviour — — Partial Correlation (partial-r): -0.0558 [-0.1434, 0.0326] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007845 — — 371 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008949 — — 513 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008503 — — 203 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009175 — — 1,218 individuals — European Poland (NE Europe) UKB —
PSS008729 — — 2,243 individuals — European Italy (South Europe) UKB —
PSS009401 — — 6,380 individuals — European UK (+ Ireland) UKB —
PSS008281 — — 811 individuals — South Asian India (South Asia) UKB —
PSS008058 — — 421 individuals — East Asian China (East Asia) UKB —