Polygenic Score (PGS) ID: PGS002127

Predicted Trait
Reported Trait Age at first live birth
Mapped Trait(s) age at first birth measurement (EFO_0009101)
Additional Trait Information sex-specific factors
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_F_age_first_birth
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 848,784
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011872 PSS009145|
European Ancestry|
768 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age at first live birth — — Partial Correlation (partial-r): 0.1972 [0.1273, 0.2652] sex, age, birth date, deprivation index, 16 PCs —
PPM011871 PSS009371|
European Ancestry|
3,989 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age at first live birth — — Partial Correlation (partial-r): 0.1829 [0.1527, 0.2128] sex, age, birth date, deprivation index, 16 PCs —
PPM011873 PSS008699|
European Ancestry|
1,149 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age at first live birth — — Partial Correlation (partial-r): 0.1779 [0.1208, 0.2338] sex, age, birth date, deprivation index, 16 PCs —
PPM011874 PSS008473|
Greater Middle Eastern Ancestry|
157 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age at first live birth — — Partial Correlation (partial-r): 0.0501 [-0.118, 0.2154] sex, age, birth date, deprivation index, 16 PCs —
PPM011875 PSS008251|
South Asian Ancestry|
1,185 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age at first live birth — — Partial Correlation (partial-r): 0.0625 [0.0051, 0.1195] sex, age, birth date, deprivation index, 16 PCs —
PPM011876 PSS008029|
East Asian Ancestry|
314 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age at first live birth — — Partial Correlation (partial-r): -0.0711 [-0.1838, 0.0434] sex, age, birth date, deprivation index, 16 PCs —
PPM011877 PSS007815|
African Ancestry|
509 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age at first live birth — — Partial Correlation (partial-r): 0.0076 [-0.081, 0.0961] sex, age, birth date, deprivation index, 16 PCs —
PPM011878 PSS008919|
African Ancestry|
746 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Age at first live birth — — Partial Correlation (partial-r): 0.0199 [-0.0529, 0.0925] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007815 — — 509 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008699 — — 1,149 individuals — European Italy (South Europe) UKB —
PSS008919 — — 746 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008473 — — 157 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009145 — — 768 individuals — European Poland (NE Europe) UKB —
PSS008251 — — 1,185 individuals — South Asian India (South Asia) UKB —
PSS008029 — — 314 individuals — East Asian China (East Asia) UKB —
PSS009371 — — 3,989 individuals — European UK (+ Ireland) UKB —