Polygenic Score (PGS) ID: PGS002153

Predicted Trait
Reported Trait General happiness with own health
Mapped Trait(s) health satisfaction measurement (EFO_0009724)
Additional Trait Information lifestyle and environment
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_less_happy_with_health
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 824,602
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012075 PSS008303|
South Asian Ancestry|
815 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness with own health — — Partial Correlation (partial-r): 0.0875 [0.0181, 0.1561] sex, age, birth date, deprivation index, 16 PCs —
PPM012071 PSS009423|
European Ancestry|
6,445 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness with own health — — Partial Correlation (partial-r): 0.1032 [0.0789, 0.1273] sex, age, birth date, deprivation index, 16 PCs —
PPM012072 PSS009197|
European Ancestry|
1,246 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness with own health — — Partial Correlation (partial-r): 0.119 [0.0634, 0.1738] sex, age, birth date, deprivation index, 16 PCs —
PPM012073 PSS008751|
European Ancestry|
2,257 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness with own health — — Partial Correlation (partial-r): 0.0596 [0.0182, 0.1008] sex, age, birth date, deprivation index, 16 PCs —
PPM012074 PSS008525|
Greater Middle Eastern Ancestry|
199 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness with own health — — Partial Correlation (partial-r): 0.0755 [-0.072, 0.2197] sex, age, birth date, deprivation index, 16 PCs —
PPM012076 PSS008080|
East Asian Ancestry|
423 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness with own health — — Partial Correlation (partial-r): 0.0795 [-0.0183, 0.1759] sex, age, birth date, deprivation index, 16 PCs —
PPM012077 PSS007867|
African Ancestry|
374 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness with own health — — Partial Correlation (partial-r): -0.046 [-0.1495, 0.0585] sex, age, birth date, deprivation index, 16 PCs —
PPM012078 PSS008971|
African Ancestry|
511 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness with own health — — Partial Correlation (partial-r): 0.0167 [-0.0719, 0.105] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008971 — — 511 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009197 — — 1,246 individuals — European Poland (NE Europe) UKB —
PSS008525 — — 199 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009423 — — 6,445 individuals — European UK (+ Ireland) UKB —
PSS008303 — — 815 individuals — South Asian India (South Asia) UKB —
PSS008751 — — 2,257 individuals — European Italy (South Europe) UKB —
PSS008080 — — 423 individuals — East Asian China (East Asia) UKB —
PSS007867 — — 374 individuals — African American or Afro-Caribbean Carribean UKB —