Polygenic Score (PGS) ID: PGS002179

Predicted Trait
Reported Trait Impedance of whole body
Mapped Trait(s) body composition measurement (EFO_0005106)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_log_impedance
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 978,109
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012279 PSS009450|
European Ancestry|
19,624 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Impedance of whole body — — Partial Correlation (partial-r): 0.4005 [0.3887, 0.4122] sex, age, birth date, deprivation index, 16 PCs —
PPM012280 PSS009224|
European Ancestry|
4,069 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Impedance of whole body — — Partial Correlation (partial-r): 0.3968 [0.3705, 0.4224] sex, age, birth date, deprivation index, 16 PCs —
PPM012281 PSS008778|
European Ancestry|
6,535 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Impedance of whole body — — Partial Correlation (partial-r): 0.3774 [0.3564, 0.398] sex, age, birth date, deprivation index, 16 PCs —
PPM012282 PSS008552|
Greater Middle Eastern Ancestry|
1,151 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Impedance of whole body — — Partial Correlation (partial-r): 0.3911 [0.3406, 0.4394] sex, age, birth date, deprivation index, 16 PCs —
PPM012284 PSS008107|
East Asian Ancestry|
1,782 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Impedance of whole body — — Partial Correlation (partial-r): 0.2885 [0.2451, 0.3307] sex, age, birth date, deprivation index, 16 PCs —
PPM012285 PSS007894|
African Ancestry|
2,417 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Impedance of whole body — — Partial Correlation (partial-r): 0.232 [0.1937, 0.2695] sex, age, birth date, deprivation index, 16 PCs —
PPM012286 PSS008998|
African Ancestry|
3,798 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Impedance of whole body — — Partial Correlation (partial-r): 0.1673 [0.1361, 0.1981] sex, age, birth date, deprivation index, 16 PCs —
PPM012283 PSS008330|
South Asian Ancestry|
6,178 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Impedance of whole body — — Partial Correlation (partial-r): 0.3595 [0.3376, 0.3811] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008998 — — 3,798 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008552 — — 1,151 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009224 — — 4,069 individuals — European Poland (NE Europe) UKB —
PSS008778 — — 6,535 individuals — European Italy (South Europe) UKB —
PSS009450 — — 19,624 individuals — European UK (+ Ireland) UKB —
PSS008107 — — 1,782 individuals — East Asian China (East Asia) UKB —
PSS008330 — — 6,178 individuals — South Asian India (South Asia) UKB —
PSS007894 — — 2,417 individuals — African American or Afro-Caribbean Carribean UKB —