Polygenic Score (PGS) ID: PGS002186

Predicted Trait
Reported Trait Monocyte count
Mapped Trait(s) monocyte count (EFO_0005091)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_log_monocyte
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 641,455
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012335 PSS009457|
European Ancestry|
19,384 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte count — — Partial Correlation (partial-r): 0.4013 [0.3894, 0.4131] sex, age, birth date, deprivation index, 16 PCs —
PPM012336 PSS009231|
European Ancestry|
3,993 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte count — — Partial Correlation (partial-r): 0.3828 [0.356, 0.4091] sex, age, birth date, deprivation index, 16 PCs —
PPM012338 PSS008559|
Greater Middle Eastern Ancestry|
1,151 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte count — — Partial Correlation (partial-r): 0.3913 [0.3408, 0.4395] sex, age, birth date, deprivation index, 16 PCs —
PPM012339 PSS008337|
South Asian Ancestry|
6,060 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte count — — Partial Correlation (partial-r): 0.326 [0.3033, 0.3484] sex, age, birth date, deprivation index, 16 PCs —
PPM012340 PSS008114|
East Asian Ancestry|
1,760 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte count — — Partial Correlation (partial-r): 0.2727 [0.2287, 0.3157] sex, age, birth date, deprivation index, 16 PCs —
PPM012341 PSS007901|
African Ancestry|
2,336 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte count — — Partial Correlation (partial-r): 0.2009 [0.1615, 0.2396] sex, age, birth date, deprivation index, 16 PCs —
PPM012342 PSS009005|
African Ancestry|
3,699 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte count — — Partial Correlation (partial-r): 0.1818 [0.1503, 0.2128] sex, age, birth date, deprivation index, 16 PCs —
PPM012337 PSS008785|
European Ancestry|
6,423 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Monocyte count — — Partial Correlation (partial-r): 0.3692 [0.3478, 0.3901] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009005 — — 3,699 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009231 — — 3,993 individuals — European Poland (NE Europe) UKB —
PSS008559 — — 1,151 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008337 — — 6,060 individuals — South Asian India (South Asia) UKB —
PSS009457 — — 19,384 individuals — European UK (+ Ireland) UKB —
PSS008114 — — 1,760 individuals — East Asian China (East Asia) UKB —
PSS008785 — — 6,423 individuals — European Italy (South Europe) UKB —
PSS007901 — — 2,336 individuals — African American or Afro-Caribbean Carribean UKB —