Polygenic Score (PGS) ID: PGS002218

Predicted Trait
Reported Trait Overall health rating
Mapped Trait(s) health trait (EFO_0007652)
Additional Trait Information lifestyle and environment
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_poorer_health
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 958,362
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012591 PSS009484|
European Ancestry|
19,916 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overall health rating — — Partial Correlation (partial-r): 0.1836 [0.1702, 0.197] sex, age, birth date, deprivation index, 16 PCs —
PPM012592 PSS009258|
European Ancestry|
4,073 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overall health rating — — Partial Correlation (partial-r): 0.1633 [0.1332, 0.1932] sex, age, birth date, deprivation index, 16 PCs —
PPM012593 PSS008812|
European Ancestry|
6,579 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overall health rating — — Partial Correlation (partial-r): 0.1628 [0.1391, 0.1863] sex, age, birth date, deprivation index, 16 PCs —
PPM012594 PSS008586|
Greater Middle Eastern Ancestry|
1,122 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overall health rating — — Partial Correlation (partial-r): 0.1078 [0.0491, 0.1658] sex, age, birth date, deprivation index, 16 PCs —
PPM012595 PSS008364|
South Asian Ancestry|
6,144 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overall health rating — — Partial Correlation (partial-r): 0.1314 [0.1067, 0.1559] sex, age, birth date, deprivation index, 16 PCs —
PPM012596 PSS008141|
East Asian Ancestry|
1,761 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overall health rating — — Partial Correlation (partial-r): 0.0723 [0.0254, 0.1189] sex, age, birth date, deprivation index, 16 PCs —
PPM012597 PSS007928|
African Ancestry|
2,438 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overall health rating — — Partial Correlation (partial-r): 0.0718 [0.032, 0.1114] sex, age, birth date, deprivation index, 16 PCs —
PPM012598 PSS009032|
African Ancestry|
3,784 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Overall health rating — — Partial Correlation (partial-r): 0.0739 [0.0421, 0.1056] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009032 — — 3,784 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008586 — — 1,122 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009258 — — 4,073 individuals — European Poland (NE Europe) UKB —
PSS009484 — — 19,916 individuals — European UK (+ Ireland) UKB —
PSS008812 — — 6,579 individuals — European Italy (South Europe) UKB —
PSS008364 — — 6,144 individuals — South Asian India (South Asia) UKB —
PSS008141 — — 1,761 individuals — East Asian China (East Asia) UKB —
PSS007928 — — 2,438 individuals — African American or Afro-Caribbean Carribean UKB —