PGS Catalog - PGS002746 / Attention-deficit hyperactivity disorder (Polygenic Score)

Polygenic Score (PGS) ID: PGS002746

Predicted Trait
Reported Trait	Attention-deficit hyperactivity disorder
Mapped Trait(s)	attention deficit hyperactivity disorder (EFO_0003888)

Released in PGS Catalog: Sept. 8, 2022

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Score Details

Score Construction
PGS Name	PRS_ADHD
Development Method
Name	Genome-wide significant variants
Parameters	r2>0.1, p<0.05
Variants
Original Genome Build	NR
Number of Variants	513,659
Effect Weight Type	log(OR)

PGS Source
PGS Catalog Publication (PGP) ID	PGP000358
Citation (link to publication)	Lahey BB et al. J Psychiatr Res (2022)

Ancestry Distribution
Source of Variant Associations (GWAS)	European: 96.2% East Asian: 3.5% Not Reported: 0.3% 55,374 individuals (100%)
PGS Evaluation	European: 100% 1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)

Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
GWAS Catalog: GCST007543 Europe PMC: 30478444	144 individuals	Not reported	NR
GWAS Catalog: GCST007543 Europe PMC: 30478444	53,293 individuals	European	NR
GWAS Catalog: GCST007543 Europe PMC: 30478444	1,937 individuals	East Asian	NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM014920	PSS009931\| European Ancestry\| 4,483 individuals	PGP000358 \| Lahey BB et al. J Psychiatr Res (2022)	Reported Trait: Specific internalizing (at baseline)	β: -0.06 (0.02)	—	—	—	—
PPM014921	PSS009931\| European Ancestry\| 4,483 individuals	PGP000358 \| Lahey BB et al. J Psychiatr Res (2022)	Reported Trait: Specific conduct problem (1-year follow-up)	β: 0.09 (0.02)	—	—	—	—
PPM014922	PSS009931\| European Ancestry\| 4,483 individuals	PGP000358 \| Lahey BB et al. J Psychiatr Res (2022)	Reported Trait: Specific ADHD (1-year follow-up)	β: 0.11 (0.03)	—	—	—	—
PPM014924	PSS009931\| European Ancestry\| 4,483 individuals	PGP000358 \| Lahey BB et al. J Psychiatr Res (2022)	Reported Trait: UPPS Impulsive Behavior Scale (Positive urgency)	β: 0.046 (0.016)	—	—	Age, sex, and the first 10 principal components of population structure	—
PPM014925	PSS009931\| European Ancestry\| 4,483 individuals	PGP000358 \| Lahey BB et al. J Psychiatr Res (2022)	Reported Trait: Latent executive functioning	β: -0.042	—	—	Age, sex, and the first 10 principal components of population structure	—
PPM014919	PSS009931\| European Ancestry\| 4,483 individuals	PGP000358 \| Lahey BB et al. J Psychiatr Res (2022)	Reported Trait: General factor of psychological problems (1-year follow-up)	β: 0.07 (0.02)	—	—	—	—
PPM014923	PSS009931\| European Ancestry\| 4,483 individuals	PGP000358 \| Lahey BB et al. J Psychiatr Res (2022)	Reported Trait: UPPS Impulsive Behavior Scale (Low perseverance)	β: 0.043 (0.017)	—	—	Age, sex, and the first 10 principal components of population structure	—

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS009931	—		4,483 individuals, 53.2 % Male samples	Mean = 118.94 months Sd = 7.48 months	European	—	NR	ABCD