Polygenic Score (PGS) ID: PGS003353

Predicted Trait
Reported Trait Type 2 diabetes (T2D)
Mapped Trait(s) type 2 diabetes mellitus (MONDO_0005148)
Released in PGS Catalog: Dec. 20, 2022
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Score Details

Score Construction
PGS Name GRS_T2D
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 287
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000405
Citation (link to publication) Kim YJ et al. Nat Commun (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
433,540 individuals (100%)
PGS Evaluation
Greater Middle Eastern: 66.7%
East Asian: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST010118
Europe PMC: 32499647
 433,540 individuals East Asian AGEN

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016201 PSS010055|
East Asian Ancestry|
22,608 individuals
 PGP000405 |
Kim YJ et al. Nat Commun (2022)
 Reported Trait: Fasting plasma glucose OR: 1.83 [1.59, 2.11] — — — —
PPM016202 PSS010055|
East Asian Ancestry|
22,608 individuals
 PGP000405 |
Kim YJ et al. Nat Commun (2022)
 Reported Trait: Hemoglobin A1c level OR: 1.68 [1.46, 1.93] — — — —
PPM016203 PSS010055|
East Asian Ancestry|
22,608 individuals
 PGP000405 |
Kim YJ et al. Nat Commun (2022)
 Reported Trait: Type 2 diabetes OR: 2.99 [2.61, 3.44] — — — —
PPM016204 PSS010055|
East Asian Ancestry|
22,608 individuals
 PGP000405 |
Kim YJ et al. Nat Commun (2022)
 Reported Trait: Fasting plasma glucose and Type 2 diabetes OR: 3.52 [2.69, 4.61] — — — —
PPM022824 PSS012080|
Greater Middle Eastern Ancestry|
4,534 individuals
 PGP000753 |
Aliyu U et al. Diabetes Obes Metab (2025)
|Ext.		 Reported Trait: Prediabetes OR: 1.213 [1.14, 1.291] AUROC: 0.651 [0.635, 0.667] R²: 0.086 sex, baseline age, BMI, PCs1-10 —
PPM022918 PSS012081|
Greater Middle Eastern Ancestry|
2,143 individuals
 PGP000753 |
Aliyu U et al. Diabetes Obes Metab (2025)
|Ext.		 Reported Trait: Incident T2D in prediabetics HR: 1.489 [1.285, 1.725] AUROC: 0.765 [0.73, 0.8] — sex, baseline age, BMI, PCs1-10 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010055 — — 22,608 individuals — East Asian — KBA, KoGES —
PSS012080 age-matched cohort —
[
  • 2,267 cases
  • , 2,267 controls
]
 — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 — QBB —
PSS012081 — Median = 6.0 years
[
  • 199 cases
  • , 1,944 controls
]
,
54.22 % Male samples
 — Greater Middle Eastern (Middle Eastern, North African or Persian)
(Qatari)		 — QBB —