Polygenic Score (PGS) ID: PGS003421

Predicted Trait
Reported Trait Ankylosing spondylitis
Mapped Trait(s) ankylosing spondylitis (EFO_0003898)
Released in PGS Catalog: Feb. 8, 2023
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRS16_C+T
Development Method
Name Clumping and Thresholding (C+T)
Parameters NR
Variants
Original Genome Build NR
Number of Variants 16
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000431
Citation (link to publication) Ko CL et al. J Transl Med (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
144 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 21 cases
  • , 124 controls
]
 East Asian
(Taiwanese)		 NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017074 PSS010115|
East Asian Ancestry|
1,298 individuals
 PGP000431 |
Ko CL et al. J Transl Med (2022)
 Reported Trait: Ankylosing spondylitis — AUROC: 0.7876 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010115 — —
[
  • 185 cases
  • , 1,112 controls
]
 — East Asian
(Taiwanese)		 — NR TPMI