Polygenic Score (PGS) ID: PGS003442

Predicted Trait
Reported Trait Major depressive disorder
Mapped Trait(s) major depressive disorder (MONDO_0002009)
Released in PGS Catalog: March 3, 2023
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Score Details

Score Construction
PGS Name GRS8_MD
Development Method
Name Genome-wide significant SNPs
Parameters MAF < .05, r2 > .10
Variants
Original Genome Build NR
Number of Variants 8
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000444
Citation (link to publication) Petrican R et al. Sci Rep (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 55.3%
Not Reported: 44.7%
807,553 individuals (100%)
PGS Evaluation
Not Reported: 100%
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007342
Europe PMC: 30718901
 361,315 individuals Not reported NR
GWAS Catalog: GCST007342
Europe PMC: 30718901
 446,238 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017180 PSS010155|
Ancestry Not Reported|
117 individuals
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Reported Trait: Fluid cognition via average SST BOLD activation in adoptees β: 0.064 (0.027) — — — —
PPM017181 PSS010156|
Ancestry Not Reported|
4,382 individuals
 PGP000444 |
Petrican R et al. Sci Rep (2023)
 Reported Trait: Fluid cognition via verage SST BOLD activation in non-adoptees β: 0.0 (0.004) — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010155 — — 117 individuals,
50.0 % Male samples
 Mean = 9.96 years Not reported — NR ABCD
PSS010156 — — 4,382 individuals,
50.0 % Male samples
 Mean = 9.94 years Not reported — NR ABCD