Polygenic Score (PGS) ID: PGS003494

Predicted Trait
Reported Trait Birth weight
Mapped Trait(s) birth weight (EFO_0004344)
Released in PGS Catalog: April 12, 2023
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Score Details

Score Construction
PGS Name cont-decay-birth_weight
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
209,524 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 209,524 individuals,
0.39 % Male samples
 European UKB — Mean = 55.4 years
Sd = 8.0 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017422 PSS010903|
European Ancestry|
11,297 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Birth weight — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM017506 PSS010819|
European Ancestry|
2,136 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Birth weight — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM017590 PSS010651|
European Ancestry|
3,340 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Birth weight — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM017674 PSS010567|
Greater Middle Eastern Ancestry|
303 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Birth weight — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017842 PSS010483|
South Asian Ancestry|
1,501 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Birth weight — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017926 PSS010399|
East Asian Ancestry|
713 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Birth weight — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM018010 PSS010315|
African Ancestry|
838 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Birth weight — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017758 PSS010231|
European Ancestry|
1,260 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Birth weight — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM018094 PSS010735|
African Ancestry|
785 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Birth weight — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010231 — — 1,260 individuals,
39.0 % Male samples
 Mean = 57.0 years
Sd = 7.2 years		 European Ashkenazi UKB —
PSS010399 — — 713 individuals,
27.0 % Male samples
 Mean = 50.5 years
Sd = 7.2 years		 East Asian Chinese UKB —
PSS010819 — — 2,136 individuals,
34.0 % Male samples
 Mean = 52.8 years
Sd = 7.2 years		 European Polish UKB —
PSS010567 — — 303 individuals,
55.0 % Male samples
 Mean = 51.1 years
Sd = 7.8 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010315 — — 838 individuals,
34.0 % Male samples
 Mean = 50.5 years
Sd = 7.6 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010735 — — 785 individuals,
39.0 % Male samples
 Mean = 50.4 years
Sd = 8.0 years		 African unspecified Nigerian UKB —
PSS010483 — — 1,501 individuals,
49.0 % Male samples
 Mean = 51.1 years
Sd = 8.2 years		 South Asian Indian UKB —
PSS010903 — — 11,297 individuals,
39.0 % Male samples
 Mean = 55.5 years
Sd = 8.0 years		 European white British UKB —
PSS010651 — — 3,340 individuals,
39.0 % Male samples
 Mean = 52.8 years
Sd = 8.2 years		 European Italian UKB —