Polygenic Score (PGS) ID: PGS003503

Predicted Trait
Reported Trait Red blood cell (erythrocyte) distribution width
Mapped Trait(s) Red cell distribution width (EFO_0009188)
Released in PGS Catalog: April 12, 2023
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Score Details

Score Construction
PGS Name cont-decay-erythrocyte_width
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
359,224 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 359,224 individuals,
0.46 % Male samples
 European UKB — Mean = 56.9 years
Sd = 8.0 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017431 PSS010864|
European Ancestry|
19,389 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Red blood cell (erythrocyte) distribution width — — partial-R2: 0.11 sex, age, deprivation index, PC1-16 —
PPM017515 PSS010780|
European Ancestry|
3,985 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Red blood cell (erythrocyte) distribution width — — partial-R2: 0.1 sex, age, deprivation index, PC1-16 —
PPM017599 PSS010612|
European Ancestry|
6,263 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Red blood cell (erythrocyte) distribution width — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM017683 PSS010528|
Greater Middle Eastern Ancestry|
1,114 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Red blood cell (erythrocyte) distribution width — — partial-R2: 0.07 sex, age, deprivation index, PC1-16 —
PPM017851 PSS010444|
South Asian Ancestry|
5,983 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Red blood cell (erythrocyte) distribution width — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM017935 PSS010360|
East Asian Ancestry|
1,744 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Red blood cell (erythrocyte) distribution width — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM018019 PSS010276|
African Ancestry|
2,315 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Red blood cell (erythrocyte) distribution width — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017767 PSS010192|
European Ancestry|
2,258 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Red blood cell (erythrocyte) distribution width — — partial-R2: 0.09 sex, age, deprivation index, PC1-16 —
PPM018103 PSS010696|
African Ancestry|
3,651 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Red blood cell (erythrocyte) distribution width — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010528 — — 1,114 individuals,
60.0 % Male samples
 Mean = 52.0 years
Sd = 8.0 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010276 — — 2,315 individuals,
37.0 % Male samples
 Mean = 52.5 years
Sd = 8.1 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010696 — — 3,651 individuals,
47.0 % Male samples
 Mean = 51.9 years
Sd = 8.1 years		 African unspecified Nigerian UKB —
PSS010444 — — 5,983 individuals,
55.0 % Male samples
 Mean = 53.3 years
Sd = 8.4 years		 South Asian Indian UKB —
PSS010864 — — 19,389 individuals,
46.0 % Male samples
 Mean = 56.9 years
Sd = 7.9 years		 European white British UKB —
PSS010192 — — 2,258 individuals,
45.0 % Male samples
 Mean = 58.0 years
Sd = 7.1 years		 European Ashkenazi UKB —
PSS010612 — — 6,263 individuals,
45.0 % Male samples
 Mean = 54.5 years
Sd = 8.4 years		 European Italian UKB —
PSS010360 — — 1,744 individuals,
33.0 % Male samples
 Mean = 52.5 years
Sd = 7.8 years		 East Asian Chinese UKB —
PSS010780 — — 3,985 individuals,
38.0 % Male samples
 Mean = 54.3 years
Sd = 7.5 years		 European Polish UKB —