Polygenic Score (PGS) ID: PGS003510

Predicted Trait
Reported Trait Fluid intelligence score
Mapped Trait(s) intelligence (EFO_0004337)
Released in PGS Catalog: April 12, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name cont-decay-fluid_intelligence
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
94,746 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 94,746 individuals,
0.45 % Male samples
 European UKB — Mean = 56.3 years
Sd = 7.6 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017438 PSS010872|
European Ancestry|
5,148 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Fluid intelligence score — — partial-R2: 0.06 sex, age, deprivation index, PC1-16 —
PPM017522 PSS010788|
European Ancestry|
983 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Fluid intelligence score — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017606 PSS010620|
European Ancestry|
1,785 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Fluid intelligence score — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017690 PSS010536|
Greater Middle Eastern Ancestry|
158 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Fluid intelligence score — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017774 PSS010200|
European Ancestry|
799 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Fluid intelligence score — — partial-R2: 0.05 sex, age, deprivation index, PC1-16 —
PPM017858 PSS010452|
South Asian Ancestry|
652 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Fluid intelligence score — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017942 PSS010368|
East Asian Ancestry|
345 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Fluid intelligence score — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM018026 PSS010284|
African Ancestry|
266 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Fluid intelligence score — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM018110 PSS010704|
African Ancestry|
322 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: Fluid intelligence score — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010368 — — 345 individuals,
27.0 % Male samples
 Mean = 52.1 years
Sd = 7.6 years		 East Asian Chinese UKB —
PSS010200 — — 799 individuals,
43.0 % Male samples
 Mean = 57.7 years
Sd = 6.9 years		 European Ashkenazi UKB —
PSS010788 — — 983 individuals,
35.0 % Male samples
 Mean = 54.1 years
Sd = 7.4 years		 European Polish UKB —
PSS010536 — — 158 individuals,
56.0 % Male samples
 Mean = 54.5 years
Sd = 7.6 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010284 — — 266 individuals,
34.0 % Male samples
 Mean = 50.4 years
Sd = 7.1 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010704 — — 322 individuals,
47.0 % Male samples
 Mean = 50.6 years
Sd = 7.4 years		 African unspecified Nigerian UKB —
PSS010452 — — 652 individuals,
54.0 % Male samples
 Mean = 52.5 years
Sd = 8.3 years		 South Asian Indian UKB —
PSS010872 — — 5,148 individuals,
46.0 % Male samples
 Mean = 56.4 years
Sd = 7.6 years		 European white British UKB —
PSS010620 — — 1,785 individuals,
42.0 % Male samples
 Mean = 54.1 years
Sd = 8.1 years		 European Italian UKB —