Polygenic Score (PGS) ID: PGS003518

Predicted Trait
Reported Trait General happiness
Mapped Trait(s) wellbeing measurement (EFO_0007869)
Released in PGS Catalog: April 12, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name cont-decay-less_happy
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
119,828 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 119,828 individuals,
0.44 % Male samples
 European UKB — Mean = 56.2 years
Sd = 7.6 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017446 PSS010880|
European Ancestry|
6,472 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: General happiness — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017530 PSS010796|
European Ancestry|
1,241 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: General happiness — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM017614 PSS010628|
European Ancestry|
2,169 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: General happiness — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017698 PSS010544|
Greater Middle Eastern Ancestry|
199 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: General happiness — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017782 PSS010208|
European Ancestry|
940 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: General happiness — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017866 PSS010460|
South Asian Ancestry|
809 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: General happiness — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM017950 PSS010376|
East Asian Ancestry|
425 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: General happiness — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM018034 PSS010292|
African Ancestry|
368 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: General happiness — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —
PPM018118 PSS010712|
African Ancestry|
502 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: General happiness — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010880 — — 6,472 individuals,
45.0 % Male samples
 Mean = 56.2 years
Sd = 7.7 years		 European white British UKB —
PSS010208 — — 940 individuals,
43.0 % Male samples
 Mean = 57.6 years
Sd = 7.0 years		 European Ashkenazi UKB —
PSS010628 — — 2,169 individuals,
41.0 % Male samples
 Mean = 54.0 years
Sd = 8.1 years		 European Italian UKB —
PSS010376 — — 425 individuals,
27.0 % Male samples
 Mean = 52.4 years
Sd = 7.3 years		 East Asian Chinese UKB —
PSS010796 — — 1,241 individuals,
34.0 % Male samples
 Mean = 54.0 years
Sd = 7.3 years		 European Polish UKB —
PSS010544 — — 199 individuals,
56.0 % Male samples
 Mean = 53.8 years
Sd = 7.2 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —
PSS010292 — — 368 individuals,
32.0 % Male samples
 Mean = 50.5 years
Sd = 7.4 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010712 — — 502 individuals,
48.0 % Male samples
 Mean = 50.7 years
Sd = 7.2 years		 African unspecified Nigerian UKB —
PSS010460 — — 809 individuals,
57.0 % Male samples
 Mean = 52.7 years
Sd = 8.2 years		 South Asian Indian UKB —