Polygenic Score (PGS) ID: PGS003529

Predicted Trait
Reported Trait QRS duration
Mapped Trait(s) QRS duration (EFO_0005055)
Released in PGS Catalog: April 12, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name cont-decay-log_ECG_QRS_duration
Development Method
Name LDpred2-auto
Parameters vec_p_init = seq_log(1e-4, 0.9, length.out = 10), burn_in = 100, num_iter = 500, report_step = 5
Variants
Original Genome Build GRCh37
Number of Variants 979,739
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000457
Citation (link to publication) Ding Y et al. bioRxiv (2022) Preprint
Ancestry Distribution
Score Development/Training
European: 100%
28,486 individuals (100%)
PGS Evaluation
European: 44.4%
African: 22.2%
East Asian: 11.1%
Greater Middle Eastern: 11.1%
South Asian: 11.1%
9 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 28,486 individuals,
0.49 % Male samples
 European UKB — Mean = 55.2 years
Sd = 7.4 years		 — white British —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017457 PSS010893|
European Ancestry|
1,567 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QRS duration — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017541 PSS010809|
European Ancestry|
299 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QRS duration — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017625 PSS010641|
European Ancestry|
400 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QRS duration — — partial-R2: 0.03 sex, age, deprivation index, PC1-16 —
PPM017709 PSS010557|
Greater Middle Eastern Ancestry|
42 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QRS duration — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM017793 PSS010221|
European Ancestry|
186 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QRS duration — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM017961 PSS010389|
East Asian Ancestry|
115 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QRS duration — — partial-R2: 0.01 sex, age, deprivation index, PC1-16 —
PPM018129 PSS010725|
African Ancestry|
116 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QRS duration — — partial-R2: 0.02 sex, age, deprivation index, PC1-16 —
PPM017877 PSS010473|
South Asian Ancestry|
253 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QRS duration — — partial-R2: 0.04 sex, age, deprivation index, PC1-16 —
PPM018045 PSS010305|
African Ancestry|
67 individuals
 PGP000457 |
Ding Y et al. bioRxiv (2022)
|Pre		 Reported Trait: QRS duration — — partial-R2: 0.0 sex, age, deprivation index, PC1-16 —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010305 — — 67 individuals,
30.0 % Male samples
 Mean = 49.8 years
Sd = 6.5 years		 African American or Afro-Caribbean Caribbean UKB —
PSS010725 — — 116 individuals,
55.0 % Male samples
 Mean = 49.4 years
Sd = 6.7 years		 African unspecified Nigerian UKB —
PSS010473 — — 253 individuals,
66.0 % Male samples
 Mean = 51.4 years
Sd = 7.9 years		 South Asian Indian UKB —
PSS010221 — — 186 individuals,
55.0 % Male samples
 Mean = 56.5 years
Sd = 6.4 years		 European Ashkenazi UKB —
PSS010893 — — 1,567 individuals,
50.0 % Male samples
 Mean = 55.5 years
Sd = 7.4 years		 European white British UKB —
PSS010641 — — 400 individuals,
47.0 % Male samples
 Mean = 53.6 years
Sd = 7.5 years		 European Italian UKB —
PSS010389 — — 115 individuals,
35.0 % Male samples
 Mean = 51.1 years
Sd = 6.9 years		 East Asian Chinese UKB —
PSS010809 — — 299 individuals,
38.0 % Male samples
 Mean = 52.9 years
Sd = 6.6 years		 European Polish UKB —
PSS010557 — — 42 individuals,
62.0 % Male samples
 Mean = 53.8 years
Sd = 6.7 years		 Greater Middle Eastern (Middle Eastern, North African or Persian) Iranian UKB —