Polygenic Score (PGS) ID: PGS003743

Predicted Trait
Reported Trait Prostate cancer
Mapped Trait(s) prostate carcinoma (EFO_0001663)
Released in PGS Catalog: June 1, 2023
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Score Details

Score Construction
PGS Name PRS118_PrC
Development Method
Name Genome-wide significant SNPs
Parameters imputation info score ≥0.3, MAF ≥ 0.01
Variants
Original Genome Build GRCh37
Number of Variants 118
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000470
Citation (link to publication) Xin J et al. EBioMedicine (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
140,254 individuals (100%)
Score Development/Training
European: 100%
4,882 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006085
Europe PMC: 29892016
 140,254 individuals European NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 4,882 individuals European UKB — Mean = 66.77 years — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM018499 PSS010992|
European Ancestry|
408 individuals
 PGP000470 |
Xin J et al. EBioMedicine (2023)
 Reported Trait: Prostate cancer OR: 1.58 [1.41, 1.76] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010992 — — 408 individuals Mean = 61.67 years European — TCGA —