Polygenic Score (PGS) ID: PGS003937

Predicted Trait
Reported Trait Monocyte count
Mapped Trait(s) monocyte count (EFO_0005091)
Additional Trait Information http://ipgs.mit.edu/tanigawakellis2023/INI30130
Released in PGS Catalog: Nov. 1, 2023
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Score Details

Score Construction
PGS Name INI30130
Development Method
Name snpnet
Parameters inclusive PGS
Variants
Original Genome Build GRCh37
Number of Variants 13,415
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000502
Citation (link to publication) Tanigawa Y et al. AJHG (2023)
Ancestry Distribution
Score Development/Training
Multi-ancestry (including European): 100%
  • European
  • South Asian
  • African
  • Additional Diverse Ancestries
315,523 individuals (100%)
PGS Evaluation
European: 40%
African: 20%
Multi-ancestry (excluding European): 20%
  • East Asian
  • Additional Diverse Ancestries
South Asian: 20%
5 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 315,523 individuals European, South Asian, African unspecified, Other admixed ancestry UKB — — — European, South Asian, African unspecified, Other admixed ancestry —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019004 PSS011139|
European Ancestry|
65,814 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Monocyte count — — R²: 0.12426 [0.11961, 0.12891]
PGS R2 (no covariates): 0.08189 [0.07793, 0.08585]
Incremental R2 (full-covars): 0.08198		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019005 PSS011110|
European Ancestry|
2,810 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Monocyte count — — R²: 0.14509 [0.12139, 0.16879]
PGS R2 (no covariates): 0.0898 [0.06995, 0.10965]
Incremental R2 (full-covars): 0.08851		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019006 PSS011112|
South Asian Ancestry|
1,428 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Monocyte count — — R²: 0.11251 [0.08232, 0.1427]
PGS R2 (no covariates): 0.07028 [0.04528, 0.09527]
Incremental R2 (full-covars): 0.06806		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019007 PSS011154|
African Ancestry|
1,154 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Monocyte count — — R²: 0.0334 [0.01357, 0.05322]
PGS R2 (no covariates): 0.03342 [0.01359, 0.05325]
Incremental R2 (full-covars): 0.02807		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —
PPM019008 PSS011168|
Multi-ancestry (excluding European)|
7,732 individuals
 PGP000502 |
Tanigawa Y et al. AJHG (2023)
 Reported Trait: Monocyte count — — R²: 0.11068 [0.09772, 0.12363]
PGS R2 (no covariates): 0.07932 [0.06797, 0.09067]
Incremental R2 (full-covars): 0.06798		 age, sex, age^2, age*sex, Townsend deprivation index, genotype PCs (PC1-PC18) —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011110 — — 2,810 individuals — European
(non-white British ancestry)		 — UKB —
PSS011112 — — 1,428 individuals — South Asian — UKB —
PSS011154 — — 1,154 individuals — African unspecified — UKB —
PSS011168 — — 7,732 individuals — East Asian, Other admixed ancestry East Asian, Other admixed ancestry UKB —
PSS011139 — — 65,814 individuals — European
(white British ancestry)		 — UKB —