Polygenic Score (PGS) ID: PGS003953

Predicted Trait
Reported Trait Alzheimer's disease
Mapped Trait(s) Alzheimer disease (MONDO_0004975)
Released in PGS Catalog: Oct. 17, 2023
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Score Details

Score Construction
PGS Name AD_Bellenguez
Development Method
Name PRSice-2
Parameters NR
Variants
Original Genome Build NR
Number of Variants 1,937
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000503
Citation (link to publication) Sofer T et al. Alzheimers Res Ther (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
487,511 individuals (100%)
PGS Evaluation
Hispanic or Latin American: 50%
Multi-ancestry (including European): 50%
  • African
  • Additional Asian Ancestries
  • European
  • Hispanic or Latin American
  • Not Reported
2 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90027158
Europe PMC: 35379992
 487,511 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019088 PSS011180|
Hispanic or Latin American Ancestry|
4,189 individuals
 PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
 Reported Trait: Mild cognitive impairment OR: 1.06 [0.96, 1.18] — — age at the HCHS/SOL baseline visit, time from HCHS/SOL baseline to the SOL-INCA visit, sex, study center, 5 principal components, and APOE-ϵ4 and APOE-ϵ2 allele counts —
PPM019090 PSS011179|
Multi-ancestry (including European)|
23,157 individuals
 PGP000503 |
Sofer T et al. Alzheimers Res Ther (2023)
 Reported Trait: Mild cognitive impairment (with Alzheimer's disease) OR: 1.13 (0.04) — — two SNPs defining the APOE alleles —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011179 — — 1,005 individuals — African unspecified — MGBB —
PSS011179 — — 306 individuals — Asian unspecified — MGBB —
PSS011179 — — 20,348 individuals — European — MGBB —
PSS011179 — — 614 individuals — Hispanic or Latin American — MGBB —
PSS011179 — — 884 individuals — Not reported — MGBB —
PSS011180 — — 4,189 individuals Mean = 63.0 years Hispanic or Latin American
(Central American, South American, Mexican, Cuban, Dominican, Puerto-Rican)		 — SOL SOL-INCA: Study of Latinos-Investigation of Neurocognitive Aging