Polygenic Score (PGS) ID: PGS003961

Predicted Trait
Reported Trait Diastolic blood pressure
Mapped Trait(s) diastolic blood pressure (EFO_0006336)
Released in PGS Catalog: Oct. 17, 2023
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Score Details

Score Construction
PGS Name DBP_AFR
Development Method
Name PRSice-2, LDpred2-auto
Parameters R2 = 0.1
Variants
Original Genome Build NR
Number of Variants 1,221,464
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000510
Citation (link to publication) Kurniansyah N et al. Nat Commun (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 81%
East Asian: 11.3%
African: 5.2%
Hispanic or Latin American: 1.9%
Additional Asian Ancestries: 0.4%
Additional Diverse Ancestries: 0.2%
1,213,107 individuals (100%)
Score Development/Training
European: 49.5%
African: 23.6%
Hispanic or Latin American: 19.4%
Additional Asian Ancestries: 7.5%
62,491 individuals (100%)

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007271
Europe PMC: 30578418
 225,112 individuals European MVP
GWAS Catalog: GCST007271
Europe PMC: 30578418
 63,490 individuals African unspecified MVP
GWAS Catalog: GCST007271
Europe PMC: 30578418
 22,802 individuals Hispanic or Latin American MVP
GWAS Catalog: GCST007271
Europe PMC: 30578418
 4,792 individuals Asian unspecified MVP
GWAS Catalog: GCST007271
Europe PMC: 30578418
 2,695 individuals Native American MVP
GWAS Catalog: GCST005978
Europe PMC: 29403010
 136,615 individuals East Asian BBJ
GWAS Catalog: GCST006630
Europe PMC: 30224653
 757,601 individuals European ICBP, UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 14,746 individuals,
36.9 % Male samples
 African unspecified 10 cohorts
  • ARIC
  • ,BioMe
  • ,CARDIA
  • ,CFS
  • ,CHS
  • ,COPDGene
  • ,GENOA
  • ,JHS
  • ,MESA
  • ,WHI
 — Mean = 53.94 years
Sd = 14.34 years		 — — —
— 4,671 individuals,
48.4 % Male samples
 Asian unspecified BioMe, GenSalt, MESA, WHI — Mean = 48.35 years
Sd = 12.97 years		 — — THRV (NHLBI TOPMed: Rare Variants for Hypertension in Taiwan Chinese)
— 30,943 individuals,
33.8 % Male samples
 European 11 cohorts
  • AMISH
  • ,ARIC
  • ,BioMe
  • ,CARDIA
  • ,CFS
  • ,CHS
  • ,COPDGene
  • ,FHS
  • ,GenSalt
  • ,MESA
  • ,WHI
 — Mean = 57.85 years
Sd = 14.59 years		 — — —
— 12,131 individuals,
40.0 % Male samples
 Hispanic or Latin American 7 cohorts
  • BioMe
  • ,CHS
  • ,FHS
  • ,HCHS
  • ,MESA
  • ,SOL
  • ,WHI
 — Mean = 51.27 years
Sd = 14.57 years		 — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information