Polygenic Score (PGS) ID: PGS003972

Predicted Trait
Reported Trait Abdominal aortic aneurysm
Mapped Trait(s) Abdominal Aortic Aneurysm (EFO_0004214)
Released in PGS Catalog: Nov. 1, 2023
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name PRSAAA
Development Method
Name PRS-CS
Parameters NR
Variants
Original Genome Build NR
Number of Variants 1,118,997
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000513
Citation (link to publication) Roychowdhury T et al. Nat Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 92%
African: 8%
1,125,328 individuals (100%)
PGS Evaluation
European: 100%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 37,214 cases
  • , 997,776 controls
]
 European 14 cohorts
  • ARIC
  • ,CHB
  • ,CHIP
  • ,HUNT
  • ,MAYO-VDB
  • ,MGI
  • ,MyCode
  • ,NZ
  • ,PMB
  • ,TABS
  • ,UKAGS
  • ,UKB
  • ,VIVA
  • ,deCODE
—
[
  • 2,007 cases
  • , 88,331 controls
]
 African unspecified MVP, eMERGE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM019134 PSS011199|
European Ancestry|
6,940 individuals
 PGP000513 |
Roychowdhury T et al. Nat Genet (2023)
 Reported Trait: Abdominal aortic aneurysm — AUROC: 0.69 — — —
PPM019135 PSS011197|
European Ancestry|
7,324 individuals
 PGP000513 |
Roychowdhury T et al. Nat Genet (2023)
 Reported Trait: Abdominal aortic aneurysm — AUROC: 0.66 — — —
PPM019136 PSS011198|
European Ancestry|
3,768 individuals
 PGP000513 |
Roychowdhury T et al. Nat Genet (2023)
 Reported Trait: Abdominal aortic aneurysm — AUROC: 0.64 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011197 — —
[
  • 1,887 cases
  • , 5,437 controls
]
 — European — WTCCC —
PSS011198 — —
[
  • 663 cases
  • , 3,105 controls
]
 — European — UCC-SMART —
PSS011199 — —
[
  • 1,130 cases
  • , 5,810 controls
]
 — European — OxAAA, UKAGS, UKB, UppsalaAAA, VIVA —