Polygenic Score (PGS) ID: PGS004316

Predicted Trait
Reported Trait Psoriasis
Mapped Trait(s) psoriasis (EFO_0000676)
Released in PGS Catalog: Jan. 11, 2024
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Score Details

Score Construction
PGS Name GRS-HLA
Development Method
Name Genome-wide significant SNPs
Parameters p <5.0E-08
Variants
Original Genome Build NR
Number of Variants 11
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000547
Citation (link to publication) Bui A et al. Front Genet (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
287,323 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004346
Europe PMC: 28537254
 287,323 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020385 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Age of psoriasis onset OR: 0.46 [0.34, 0.63] — R²: 0.0398 — —
PPM020387 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Age of type1 psoriasis onset OR: 0.69 [0.56, 0.86] — R²: 0.0216 — —
PPM020389 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Psoriasis severity OR: 1.09 [1.03, 1.15] — R²: 0.077 — —
PPM020391 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Total number of locations ever affected by psoriasis OR: 1.34 [1.24, 1.45] — R²: 0.077 — —
PPM020394 PSS011349|
European Ancestry|
654 individuals
 PGP000547 |
Bui A et al. Front Genet (2023)
 Reported Trait: Initial presentation of psoriasis at elbow or knee OR: 0.92 [0.88, 0.96] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011349 — — 654 individuals,
48.0 % Male samples
 Mean = 41.0 years
Sd = 14.0 years		 European — NR —