Polygenic Score (PGS) ID: PGS004321

Predicted Trait
Reported Trait Coronary heart disease
Mapped Trait(s) coronary artery disease (EFO_0001645)
Released in PGS Catalog: Jan. 11, 2024
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Score Details

Score Construction
PGS Name PRS27_CAD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build GRCh38
Number of Variants 27
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000554
Citation (link to publication) Marston NA et al. Circulation (2019)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • European
  • Not Reported
63,731 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST004787
Europe PMC: 28714975
 63,731 individuals European, NR NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020426 PSS011357|
European Ancestry|
14,298 individuals
 PGP000554 |
Marston NA et al. Circulation (2019)
 Reported Trait: Major vascular events (placebo arm) HR: 1.1 [1.03, 1.18] — — — —
PPM020427 PSS011357|
European Ancestry|
14,298 individuals
 PGP000554 |
Marston NA et al. Circulation (2019)
 Reported Trait: Major coronary events (placebo arm) HR: 1.17 [1.08, 1.26] — — — —
PPM020428 PSS011357|
European Ancestry|
14,298 individuals
 PGP000554 |
Marston NA et al. Circulation (2019)
 Reported Trait: Major vascular events (evolocumab vs placebo) — — p-value (pvalue, evolocumab and high PRS vs. placebo and low PRS): 0.07 — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011357 — — 14,298 individuals — European — FOURIER —