Polygenic Score (PGS) ID: PGS004322

Predicted Trait
Reported Trait Ischemic stroke
Mapped Trait(s) Ischemic stroke (HP_0002140)
Released in PGS Catalog: Jan. 11, 2024
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Score Details

Score Construction
PGS Name GRS30_IS
Development Method
Name Genome-wide significant SNPs
Parameters p<5E-08,r2<0.2
Variants
Original Genome Build NR
Number of Variants 30
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000555
Citation (link to publication) McElligott B et al. Front Cardiovasc Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
440,328 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006908
Europe PMC: 29531354
 440,328 individuals European MEGASTROKE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020429 PSS011358|
European Ancestry|
454,493 individuals
 PGP000555 |
McElligott B et al. Front Cardiovasc Med (2023)
 Reported Trait: Incident ischaemic stroke HR: 1.26 [1.17, 1.35] — — age, gender, 10-yr ASCVD Risk by PCE, genetic background, and sepsis —
PPM020430 PSS011358|
European Ancestry|
454,493 individuals
 PGP000555 |
McElligott B et al. Front Cardiovasc Med (2023)
 Reported Trait: Any incident myocardial infarction, ischaemic stroke, or venous thromboembolism HR: 1.05 [1.01, 1.1] — — age, gender, 10-yr ASCVD Risk by PCE, genetic background, and sepsis —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011358 ICD-10 codes (I21, I22, I23, I24.1, and I25.2), ICD-9 codes (410, 411, 412, and 429.79) for MI, ICD-10 (I63, I64), ICD-9 (434 and 436) for IS — 454,493 individuals — European — UKB Mean age of full combined ancestry cohort = 56.9 years