Polygenic Score (PGS) ID: PGS004587

Predicted Trait
Reported Trait Atopic dermatitis
Mapped Trait(s) atopic eczema (EFO_0000274)
Released in PGS Catalog: Jan. 26, 2024
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Score Details

Score Construction
PGS Name PRS23_AD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 23
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000566
Citation (link to publication) Gu X et al. Ecotoxicol Environ Saf (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
796,661 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90027161
Europe PMC: 34454985
 796,661 individuals European EB, FinnGen, UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020707 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
 Reported Trait: Incident atopic dermatitis — — Hazard ratio (HR, high vs low PRS): 1.153 [1.037, 1.282] sex, age, Townsend index, moderate physical and household income —
PPM020708 PSS011376|
European Ancestry|
337,910 individuals
 PGP000566 |
Gu X et al. Ecotoxicol Environ Saf (2023)
 Reported Trait: Incident atopic dermatitis with air pollution level — — Hazard ratio (HR, high air pollution and high PRS vs low air pollution and low PRS): 1.523 [1.259, 1.84] sex, age, Townsend index, moderate physical and household income —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011376 — Median = 12.0 years 337,910 individuals,
45.6 % Male samples
 Mean = 57.1 years
Sd = 8.0 years		 European — UKB —