Polygenic Score (PGS) ID: PGS004591

Predicted Trait
Reported Trait Major depressive disorder
Mapped Trait(s) unipolar depression (EFO_0003761)
Released in PGS Catalog: Jan. 26, 2024
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Score Details

Score Construction
PGS Name PRS17_MDD
Development Method
Name Genome-wide significant SNPs
Parameters NR
Variants
Original Genome Build NR
Number of Variants 17
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000570
Citation (link to publication) Li D et al. BMC Med (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
326,113 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 100%
  • European
  • Additional Asian Ancestries
  • African
  • East Asian
  • Not Reported
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST006041
Europe PMC: 27479909
 326,113 individuals European 23andMe

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM020721 PSS011382|
Multi-ancestry (including European)|
354,897 individuals
 PGP000570 |
Li D et al. BMC Med (2023)
 Reported Trait: Major depressive disorder with PM2.5 air pollution — — Hazard ratio (HR, PRS in top tertile and high PM2.5 exposure vs PRS in bottom tertile and low PM2.5 exposure): 1.34 [1.23, 1.46] Age, gender, ethnicity, education level, employment status, household income, and Townsend deprivation index —
PPM020720 PSS011382|
Multi-ancestry (including European)|
354,897 individuals
 PGP000570 |
Li D et al. BMC Med (2023)
 Reported Trait: Major depressive disorder — — Hazard ratio (HR, per IQR change in PRS): 1.1 [1.07, 1.12] Age, gender, ethnicity, education level, employment status, household income, Townsend deprivation index, genotyping batch, and first 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011382 — —
[
  • 14,172 cases
  • , 326,236 controls
]
 — European — UKB —
PSS011382 — —
[
  • 165 cases
  • , 4,966 controls
]
 — Asian unspecified — UKB —
PSS011382 — —
[
  • 91 cases
  • , 3,014 controls
]
 — African unspecified — UKB —
PSS011382 — —
[
  • 8 cases
  • , 775 controls
]
 — East Asian
(Chinese)		 — UKB —
PSS011382 — —
[
  • 274 cases
  • , 5,196 controls
]
 — Not reported — UKB —